Skip to main content

Table 1 General characteristics and in-hospital mortality recorded in the two cohorts examined (n = 222 846)

From: Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates

  Explicit codes cohort n = 138 517 (62.2) Combination codes cohort n = 84 329 (37.8) RR (95 % CI)
Men 80 102 (57.8) 49 730 (59.0) 0.98 (0.97, 0.99)
Age groups (years)
 18–44 10 355 (7.5) 7093 (8.4) 0.89 (0.86, 0.92)
 45–64 30 129 (21.8) 17 187 (20.4) 1.07 (1.05, 1.09)
 65–74 29 375 (21.2) 17 159 (20.4) 1.04 (1.02, 1.06)
 75–84 44 348 (32.0) 26 801 (31.8) 1.01 (0.99, 1.02)
  > 84 24 310 (17.6) 16 089 (19.1) 0.92 (0.90, 0.94)
Categorized Charlson index
 0 32 843(23.7) 15 884 (18.8) 1.26 (1.24, 1.28)
 1–2 63 820 (46.1) 37 781 (44.8) 1.03 (1.02, 1.04)
 3–4 26 796 (19.3) 20 730 (24.6) 0.79 (0.77, 0.80)
  > 4 15 058 (10.9) 9934 (11.8) 0.92 (0.90, 0.95)
Specific comorbiditiesa
 Diabetes 29 243 (21.1) 20 207 (24.0) 0.88 (0.87, 0.90)
 Cancer 28 064 (20.3) 15 321 (18.2) 1.12 (1.09, 1.14)
 Chronic heart failure 23 053 (16.6) 14 024 (16.6) 1.00 (0.98, 1.02)
 COPD 20 624 (14.9) 14 934 (17.7) 0.84 (0.82, 0.86)
 Chronic renal disease 18 275 (13.2) 17 660 (20.9) 0.63 (0.62, 0.64)
 Liver disease 17 408 (12.6) 10 616 (12.6) 1.00 (0.97, 1.02)
 Cerebrovascular disease 10 394 (7.5) 8089 (9.6) 0.78 (0.76, 0.81)
 Dementia 8139 (5.9) 5354 (6.3) 0.93 (0.89, 0.96)
 Peripheral vascular disease 7515 (5.4) 4441 (5.3) 1.03(0.99, 1.07)
 Acute myocardial infarction 5587 (4.0) 3800 (4.5) 0.90 (0.86, 0.93)
 Surgical pathology 41 518 (30.0) 17 378 (20.6) 1.45 (1.43, 1.48)
Microbiological dataa
 Pathogens identified: 52 946 (38.2) 52 641 (62.4) 0.61 (0.60, 0.62)
 Gram-positive bacteria 21 591 (40.8) 25 804 (49.0) 0.83 (0.82, 0.85)
 Gram-negative bacteria 36 765 (69.4) 30 944 (58.8) 1.18 (1.16, 1.20)
 Fungi 1521 (2.9) 2525 (4.8) 0.60 (0.56, 0.64)
Site of infectiona
 Respiratory system 35 176 (25.4) 18 572 (22.0) 1.15 (1.13, 1.17)
 Genitourinary tract 28 517 (20.6) 22 507 (26.7) 0.77 (0.76, 0.78)
 Abdomen 16 178 (11.7) 4414 (5.2) 2.23 (2.16, 2.31)
 Central nervous system 1425 (1.0) 1082 (1.3) 0.80 (0.74, 0.87)
 Procedure-related 13 608 (9.8) 9848 (11.7) 0.84 (0.82, 0.86)
 Soft tissue 5285 (3.8) 2842 (3.4) 1.13 (1.08, 1.19)
 Others/not specified 52 838 (38.2) 19 593 (23.2) 1.64 (1.62, 1.67)
Organ dysfunction (number of organs)
 1 44 614 (32.2) 62 371 (74.0) 0.44 (0.43, 0.44)
 2 41 994 (30.3) 16 956 (20.1) 1.51 (1.48, 1.54)
  > 2 42 222 (30.5) 5002 (5.9) 5.14 (4.99, 5.30)
 Not specifiedb 9687 (7.0) 0 Not applicable
Type of organ system dysfunctiona
 Cardiovascular 97 135 (70.1) 6081 (7.2) 9.72 (9.5, 10.0)
 Respiratory 68 680 (49.6) 39 679 (47.0) 1.05 (1.04, 1.07)
 Renal 60 192 (43.5) 35 552 (42.2) 1.03 (1.02, 1.04)
 Haematological 17 300 (12.5) 8743 (10.4) 1.20 (1.17, 1.24)
 Metabolic 13 396 (9.7) 5409 (6.4) 1.51 (1.46, 1.56)
 Neurological 11 232 (8.1) 12 525 (14.9) 0.55 (0.53, 0.56)
 Hepatic 7687 (5.6) 4529 (5.4) 1.03 (0.99, 1.07)
Invasive therapeutic measures
 Mechanical ventilation 38 450 (27.8) 13 353 (15.8) 1.75 (1.71, 1.79)
 Haemodialysis 11 699 (8.5) 7847 (9.3) 0.91 (0.88, 0.93)
In-hospital death 75 495 (54.5) 24 758 (29.4) 1.86 (1.83, 1.88)
  1. Data presented as number of cases (%). aSubgroups not mutually exclusive; borgan dysfunction without number of organs specified. RR risk ratio, CI 95 confidence interval, COPD chronic obstructive pulmonary disease