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Table 2 Proposed criteria for choosing between pharmacological and non-pharmacological antipyretic methods

From: Should we treat pyrexia? And how do we do it?

Antipyretic agents Physical cooling
• Non sedated patients
• Concomitant need for analgesia
• Hypothalamic dysfunction
• Need for rapid induction
• Need for strict temperature control
• Patients with hemodynamic instability
• Failure of antipyretic agents