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Table 3 Optimization of ventilator parameters required for aerosolization of antibiotics modified from Lu et al. [121]

From: Fundamentals of aerosol therapy in critical care

• Nebulizer placement—in the inspiratory limb 10 cm proximal to Y-piece

 

• Diluted in 10 ml saline

 

• Remove HME filter

 

• Ventilation mode—volume controlled

 

• Airflow pattern—constant inspiratory flow

 

• Ventilator settings—RR 12/minute, 50 % I: E ratio, VT 8 ml/kg

 

• End-inspiratory pause, 20 % duty cycle

 

• Delivered over 60 minutes

 

• Expired aerosolized particles collected in a filter

 
  1. HME heat and moisture exchanger, RR respiratory rate, I:E inspiratory: expiratory ratio, VT tidal volume
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Critical Care

ISSN: 1364-8535