Fig. 2

Blood transcriptional profiling of patients with sepsis with and without diabetes mellitus (DM). a Volcano plot representation of differentially expressed genes of whole-blood leukocytes in sepsis patients discordant for diabetes mellitus, each compared to healthy controls. Red dots denote over-expressed genes and blue dots denote under-expressed genes. b Spearman correlation analysis of the transcriptional alterations in patients with sepsis with or without diabetes mellitus revealed almost perfect correlation. rho Spearman’s correlation coefficient, fold change (FC). c Ingenuity pathway analysis of commonly over-expressed (red bars) and under-expressed (turquoise bars) genes. –log10 (Benjamini-Hochberg (BH)) p value negative log₁₀-transformed corrected for multiple comparisons