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Table 2 Variations in PCC compositiona

From: Nonvitamin K antagonist oral anticoagulant activity: challenges in measurement and reversal

 

3 F-PCC

4 F-PCC

Bebulin®

(Baxter)

Preconativ

(Kabi)

Proplex-Tb

(Baxter)

Beriplex P/N®

(CSL Behring)

Kaskadil®

(LFFBc)

Octaplex®

(Octapharma)

Cofact®

(Sanquin)

PPSB-HT Nichiyaku

(Nihon)

Factor II

24–38

50

50

31

37

10–40

14–35

20

Factor VII

<5

NA

400

16

10

10–40

7–20

20

Factor IX

24–38

60

100

29

25

20–31

25

20

Factor X

24–38

50

50

41

40

10–40

14–35

20

Protein C

   

35

 

10–40

 

15

Protein S

   

25

 

10–40

  

Protein Z

   

36

    

Antithrombin III

   

0.6

  

<0.6

 

Heparin

<0.15 IU/IU FIX

 

<1.5

0.5

5

4–15

None

 
  1. Table reproduced with permission from Bershad and Suarez [70]
  2. 3 F-PCC 3-factor PCC, 4 F-PCC 4-factor PCC, FIX factor IX, IU international units, NA not applicable, PCC prothrombin complex concentrate
  3. aComposition in international units/ml (IU/ml)
  4. bConcentration not specified
  5. cLFFB Laboratoire Français du Fractionnement et des Biotechnologies, France
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Critical Care

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