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Table 2 Characteristics of intensive care unit patients without acute lung injury or acute respiratory distress syndrom included in randomized controlled trials

From: Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis

Study Country Research period Ventilation strategies Patients (n) Cause Study quality assessment, Jadad scale Results
PaO2/FIO2 Lung compliance (ml/cmH2O) Deaths (n) Length of ICUstay (days) Length of hospital stay (days)
Lee PC [24] 1990 USA 10/1987-02/1988 A (lower VT + lower PEEP) vs B (higher VT + lower PEEP) 103 Multiple trauma or celiotomy 5 294 ± 86/260 ± 78 NR NR 4.6 ± 1/2.7 ± 0.5 NR
Borges DL [25] 2013 Brazil 01/2011-03/2012 A (lower VT + lower PEEP) vs C (lower VT + higher PEEP) 89 CABG surgery 6 270 ± 90/328.25 ± 84.75 47.4 ± 12.5/55.8 ± 19.1 NR NR NR
Dyhr T [26] 2002 Denmark NR A (lower VT + lower PEEP) vs D (lower VT + ZEEP) 15 CABG surgery 7 379.5 ± 90/304.5 ± 97.5 58 ± 11/34 ± 10 NR NR NR
Chaney MA [27] 2000 America NR B (higher VT + lower PEEP) vs A (lower VT + lower PEEP) 25 CABG surgery 5 368.6 ± 93.6/395.1 ± 179.6 58 ± 11.4/48.2 ± 23 NR NR NR
Wrigge H [28] 2005 Germany NR B (higher VT + lower PEEP) vs C (lower VT + higher PEEP) 44 CABG surgery 6 NR NR NR 1.2 ± 0.5/ 2.1 ± 0.5 NR
Koutsoukou A [29] 2006 Greece 2005 D (lower VT+ ZEEP) vs A (lower VT + lower PEEP) 21 Severe brain damage 6 NR NR NR NR NR
Good JT Jr [30] 1979 America NR B (higher VT + lower PEEP) vs E (higher VT + ZEEP) 24 Open heart surgery 7 NR NR NR NR NR
Marvel SL [31] 1986 America 1983 E (higher VT + ZEEP) vs
B (higher VT + lower PEEP) vs F (higher VT + higher PEEP)
44 CABG surgery 7 NR NR NR NR 8.9 ± 0.4/8.8 ± 0.5
Zupancich E [32] 2005 Italy NR B (higher VT + lower PEEP) vs C (lower VT + higher PEEP) 40 CABG surgery 6 324 ± 120/344 ± 94 NR NR NR NR
Pinheiro deOliveira R [33] 2010 Brazil NR B (higher VT + lower PEEP) vs A (lower VT + lower PEEP) 20 Surgery and trauma 6 334.25 ± 82.3/299.5 ± 71.9 NR 4/3 6.5 ± 5/7.7 ± 7.6 NR
Determann RM [4] 2010 Netherlands 01/2005-12/2007 E (higher VT + ZEEP) vs D (lower VT+ ZEEP) 150 Neurosurgery/neurology, cardiothoracic surgery, and cardiology 7 NR NR 23/24 NR NR
  1. The ventilation strategies are described in “Table 1”. PaO2/FIO2 partial pressure of arterial oxygen/fraction of inspired oxygen, PEEP positive end-expiratory pressure, VT tidal volume, ZEEP zero end-expiratory pressure, NR no result reported, CABG coronary artery bypass graft