Table 2 Infection characteristics and treatment

Infection characteristics

 Sepsis

184

73.0 %

875

74.7 %

0.573

 Pneumonia

68

27.0 %

296

25.3 %

 HCA

107

42.5 %

760

64.9 %

< 0.001

Illness severity measures by day 2

 ICU admission

150

59.5 %

796

68.0 %

0.010

 Mechanical ventilation

106

42.1 %

658

56.2 %

< 0.001

 Vasopressors

39

15.5 %

206

17.6 %

0.420

Antibiotics administered by day 2

 Antipseudomonal penicillins with β-lactamase inhibitor

140

55.6 %

588

50.2 %

0.124

 Extended-spectrum cephalosporins

100

39.7 %

373

31.9 %

0.017

 Antipseudomonal fluoroquinolones

96

38.1 %

489

41.8 %

0.284

 Antipseudomonal carbapenems

37

14.7 %

350

29.9 %

< 0.001

 Aminoglycosides

25

9.9 %

204

17.4 %

0.003

 Penicillins with β-lactamase inhibitors

4

1.6 %

19

1.6 %

1.000

 Tetracyclines

3

1.2 %

6

0.5 %

0.203

 Folate pathway inhibitors

3

1.2 %

11

0.9 %

0.724

 Polymyxins

0

0.0 %

37

3.2 %

0.001

Empiric treatment appropriateness

 Non-IET

162

64.3 %

217

18.5 %

< 0.001

 IET

26

10.3 %

693

59.2 %

 Indeterminate

64

25.4 %

261

22.3 %