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Fig. 2 | Critical Care

Fig. 2

From: Acute kidney injury: from clinical to molecular diagnosis

Fig. 2

AKI is a short-term event that can, however, have sequelae up to 3 months (late recovery). A clinically manifest episode of AKI can be diagnosed by SCr or urine output allowing classification of patients into stages 1–3. Before that, however, a condition of initial or subclinical damage can be uncovered by injury biomarkers. The phase of recovery from AKI is somehow specular and while creatinine may come back to normal, partial or maladaptive repair can only be detected by injury biomarkers. The portion of the diagram below the line of normal SCr is potentially characterized by new biomarkers that allow a molecular diagnosis of AKI. AKD acute kidney disease, AKI acute kidney injury, CKD chronic kidney disease, KDIGO Kidney Disease Global Outcome Initiative, SCr serum creatinine

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