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Table 4 Univariate and multivariate analyses of mortality according to CX3CR1 messenger RNA expression in septic shock patients

From: Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients

 

Univariate analysis

Multivariate analysis

Variable

OR (95 % CI)

p Value

OR (95 % CI)

p Value

D7 mortality and CX3CR1 mRNA expression at D1

 Charlson comorbidity index score

1.09 (0.96–1.23)

0.205

  

 CX3CR1 at D1 < 0.073

3.97 (2.16–7.30)

<0.001

2.76 (1.32–5.75)

0.007

 SAPS II

1.08 (1.06–1.11)

<0.001

1.07 (1.04–1.09)

<0.001

 SOFA score at D1

1.41 (1.26–1.57)

<0.001

1.15 (1.00–1.31)

0.690

 Lactate at D1a

1.20 (1.12–1.29)

<0.001

1.06 (0.96–1.16)

0.235

D28 mortality and CX3CR1 mRNA expression at D3

 Charlson comorbidity index score

1.15 (1.00–1.33)

0.050

1.16 (0.99–1.36)

0.072

 CX3CR1 at D3 < 0.253

5.58 (2.62–11.9)

<0.001

3.98 (1.72–9.23)

0.001

 SAPS II

1.03 (1.01–1.05)

0.005

1.02 (0.99–1.04)

0.198

 SOFA score at D3

1.20 (1.11–1.30)

<0.001

1.11 (1.01–1.22)

0.031

  1. D day, SAPS II Simplified Acute Physiology Score II, SOFA Sepsis-related Organ Failure Assessment, CX3CR1 chemokine (C-X3-C motif) receptor 1
  2. Univariate and multivariate analyses of mortality were studied using logistic regression
  3. aFour missing values
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Critical Care

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