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Table 2 Univariate and multivariate analyses of mortality according to CX3CR1 messenger RNA expression in critically ill patients

From: Decreased CX3CR1 messenger RNA expression is an independent molecular biomarker of early and late mortality in critically ill patients

 

Univariate analysis

Multivariate analysis

Variable

OR (95 % CI)

p Value

OR (95 % CI)

p Value

D7 mortality and CX3CR1 mRNA expression at D1

 CX3CR1 at D1 < 0.085

4.01 (2.63–6.11)

<0.001

2.03 (1.19–3.46)

0.009

 SAPS II

1.08 (1.06–1.09)

<0.001

1.06 (1.04–1.08)

<0.001

 Sepsis

0.61 (0.40–0.94)

0.023

0.37 (0.22–0.65)

<0.001

 SOFA score at D1

1.35 (1.27–1.44)

<0.001

1.09 (1.01–1.19)

0.047

 Lactate at D1a

1.27 (1.19–1.34)

<0.001

1.11 (1.03–1.19)

0.005

 Charlson comorbidity index

1.08 (0.99–1.18)

0.085

0.99 (0.88–1.10)

0.813

D28 mortality and CX3CR1 mRNA expression at D3

 CX3CR1 at D3 < 0.246

3.33 (2.17–5.10)

<0.001

2.34 (1.45–3.77)

<0.001

 Charlson comorbidity index

1.19 (1.09–1.30)

<0.001

1.15 (1.05–1.27)

0.004

 SAPS II

1.04 (1.03–1.05)

<0.001

1.02 (1.01–1.04)

0.002

 SOFA score at D3

1.20 (1.14–1.26)

<0.001

1.11 (1.05–1.18)

0.001

 Lactate at D3b

2.12 (1.57–2.86)

<0.001

 

 Sepsis

1.07 (0.68–1.69)

0.763

 
  1. Abbreviations: D day, SAPS II Simplified Acute Physiology Score II, SOFA Sepsis-related Organ Failure Assessment, CX3CR1 chemokine (C-X3-C motif) receptor 1
  2. Univariate and multivariate analyses on mortality were studied through logistic regressions
  3. a33 missing values
  4. b140 missing values