Skip to main content

Table 2 Monocyte mRNA expression in 30-day survivors and nonsurvivors after sudden cardiac arrest

From: Inflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation

mRNA RCN ± SD CPR t1 P value CPR t2 P value CPR t3 P value
  Survivors (n = 11) Nonsurvivors (n = 18)   Survivors (n = 11) Nonsurvivors (n = 18)   Survivors (n = 12) Nonsurvivors (n = 11)  
TLR2 1.69 ± 1.00 2.16 ± 0.84 0.061 1.32 ± 0.92 1.15 ± 0.40 0.947 1.09 ± 0.41 0.68 ± 0.17 0.003
TLR4 0.40 ± 0.15 0.51 ± 0.15 0.055 0.32 ± 0.06 0.35 ± 0.12 0.740 0.35 ± 0.09 0.33 ± 0.08 0.525
IRAK3 0.70 ± 0.80 0.67 ± 0.23 0.055 0.44 ± 0.17 0.47 ± 0.18 0.611 0.61 ± 0.37 0.35 ± 0.08 0.027
IRAK4 0.29 ± 0.32 0.26 ± 0.07 0.089 0.26 ± 0.12 0.24 ± 0.09 0.521 0.30 ± 0.21 0.17 ± 0.03 0.027
NLRP1 0.48 ± 1.14 0.13 ± 0.06 0.774 0.20 ± 0.12 0.14 ± 0.06 0.134 0.26 ± 0.32 0.10 ± 0.03 0.059
NLRP3 0.53 ± 0.59 0.51 ± 0.30 0.412 0.42 ± 0.44 0.41 ± 0.52 0.877 0.42 ± 0.40 0.16 ± 0.06 0.006
AIM2 0.015 ± 0.02 0.006 ± 0.003 0.220 0.006 ± 0.003 0.006 ± 0.003 0.774 0.012 ± 0.006 0.013 ± 0.010 0.880
PYCARD 0.11 ± 0.07 0.13 ± 0.05 0.112 0.16 ± 0.05 0.17 ± 0.10 0.550 0.14 ± 0.10 0.09 ± 0.03 0.059
CASP1 0.81 ± 0.40 0.78 ± 0.24 0.912 0.82 ± 0.17 0.80 ± 0.41 0.363 0.88 ± 0.39 0.58 ± 0.11 0.019
IL1B 1.03 ± 2.67 0.50 ± 1.03 0.877 1.25 ± 3.12 0.79 ± 2.13 0.465 1.01 ± 2.49 0.04 ± 0.07 0.118
  1. Shown are monocyte mRNA expression levels, expressed as mean relative copy numbers (RCN) ± standard deviation (SD), in 30-day survivors and nonsurvivors in the first 12 h (cardiopulmonary resuscitation (CPR) t1; n = 29), after 24 h (CPR t2; n = 29), and 48 h (CPR t3; n = 23) after CPR. There was one patient in group CPR t1 who was lost to follow-up after study enrollment. Statistical hypothesis testing was performed using the Mann–Whitney U test. TLR toll-like receptor, IRAK interleukin-1 receptor-associated kinase, NLRP NLR family pyrin domain containing, AIM absent in melanoma, PYCARD PYD and CARD domain containing, CASP caspase