Table 3 Risk factors, Candida colonization (low and high grade) and infection, and antifungal therapy characteristics of patients
Included patients | n = 185* |
|---|---|
Risk factors, no. (%) | |
Broad-spectrum antibiotics | 184 (99.5) |
Urinary catheter | 183 (98.9) |
Central venous catheter | 183 (98.9) |
Arterial catheter | 165 (89.2) |
Mechanical ventilation | 156 (84.3) |
Parenteral nutrition | 155 (83.8) |
Corticosteroids | 73 (39.5) |
Renal replacement therapy | 54 (29.2) |
Candida colonization (n = 154) | |
Low-grade Candida spp. colonization, no. (%) | 130 (84.4) |
High-grade Candida spp. colonization, no. (%) | 24 (15.6) |
Candida score ≥ 3; first week/during study | 96/142 (51.9) |
Candida infection (n = 31) | |
Severity of Candida infection at diagnosis | |
No sepsis/sepsis | 3/5 |
Severe sepsis/septic shock | 9/14 |
Causative Candida spp | |
C. albicans | 16 (51.6) |
C. glabrata | 7 (22.6) |
C. parapsilosis | 3 (9.7) |
C. tropicalis | 1 3.2) |
C. krusei | 1 (3.2) |
C. dubliniensis | 1 (3.2) |
C. famata | 1 (3.2) |
C. albicans + C. glabrata | 1 (3.2) |
Time between hospital admission to infection, daysa | 16 (6.5–19.5) |
Time between ICU admission to infection, daysa | 7 (2–13) |
Hospital/ICU mortality, no. (%) | 9 (29.0/5 (16.1) |
Systemic antifungal therapy (SAT) (n = 119)** | |
Empirical therapy for suspected IC (n = 90)*** | |
Multifocal colonization, no. (%) | 50 (55.6) |
Clinical situation, no. (%) | |
No sepsis/sepsis | 8 (8.9)/17 (18.9) |
Severe sepsis/septic shock | 29 (32.2)/36 (40.0) |
APACHE II | 17.8 ± 6.2 |
SOFAa | 6 (5–9) |
Candida score | 4 (3–4) |
Time between of hospital/and beginning of SAT, daysa | 11 (7–19) |
Time between ICU admission and beginning of SAT, daysa | 7 (1–11) |
Hospital/ICU mortality, no. (%) | 29 (32.2)/23 (25.6) |
Therapy for documented infection (n = 29)*** | |
Clinical situation | |
No sepsis/sepsis | 3 (10.3)/4 (13.8) |
Severe sepsis/septic shock | 8 (27.6)/14 (48.3) |
APACHE II | 18.8 ± 6.8 |
SOFAa | 6.5 (4–10) |
Candida score | 4 (3–5) |
Time between of hospital/ICU admission and beginning of SAT, daysa | |
Candidemia (11) | 15 (4.5 ; 22)/6.5 (1 ; 16) |
Intra-abdominal candidiasis (18) | 12.5 (8 ; 17)/7 (3 ; 12) |
Antifungal agents (>1 agent/patient) | |
Days of therapy (first SAT)a | 15 (8–21) |