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Table 2 Comparison of cytokine levels

From: Effect of hemoadsorption during cardiopulmonary bypass surgery – a blinded, randomized, controlled pilot study using a novel adsorbent

 

Treatment

Preoperative

Before CPB

After CPB

2 hours after CPB

24 hours after CPB

48 hours after CPB

5.POD

IL-6, pg/ml

HA

Not traceable

Not traceable

62.9 (10.8, 98.7)

120.8 (49.0, 160.8)

111.6 (53.7, 253.5)

89.0 (61.4, 160.5)

0.4 (0, 8.3)

 

Control

Not traceable

0

63.6 (41.2, 154.9)

118.7 (68.4, 255.9)

120.9 (68.0, 198.5)

67.7 (43.7, 134.5)

8.2 (0.8, 19.4)

 

P value

 

0.3485

0.3267

0.6781

0.9837

0.3809

0.0999

IL-10, pg/ml

HA

0

0

13.1 (3.3, 18.7)

5.9 (0.5, 12.9)

0.3 (0, 4.5)

0 (0, 1.2)

0

 

Control

Not traceable

0

18.5 (5.7, 68.0)

2.3 (0, 11.6)

0

Not traceable

Not traceable

 

P value

0.3485

1.0

0.1562

0.6743

0.0347

0.0185

0.3485

TNFα-LPS, pg/ml

HA

2216 (1742, 2659)

2534 (914, 3023)

40 (1, 82)

Non fec.

Non fec.

788 (679, 1272)

1737 (843, 2535)

 

Control

3364 (2579, 4893)

3403 (1679, 4394)

77 (34, 316)

Non fec.

Non fec.

3959 (2088, 4777)

3358 (3017, 3672)

 

P value

0.004

0.1378

0.2049

  

0.0115

0.0205

HMGB1, pg/ml

HA

Non fec.

0 (0, 28.1)

Non fec.

5.7 (0, 34.2)

0 (0, 72.5)

Non fec.

Non fec.

 

Control

Non fec.

48.6 (12.7, 597.3)

Non fec.

41.5 (4.5, 266.9)

26.2 (0, 281,2)

Non fec.

Non fec.

 

P value

 

0.0208

 

0.1327

0.3724

  
  1. Values are presented as median (first quartile, third quartile). The listed P values were calculated by using Wilcoxon rank-sum tests. Abbreviations: CPB, cardiopulmonary bypass; HA, hemoadsorption; HMBG1, high-mobility group box 1; IL, interleukin; fec., fecit; POD, postoperative day; TNF-α, tumor necrosis factor-alpha; TNFα-LPS, lipopolysaccharide-induced TNF-α