Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study

Table 2 Distribution of patients in relation to the target ranges of piperacillin

Patient groups, number of patients^a	Percentages of patients who attain the targets
	trough values ≥ 22.5 mg/L		≥50 % of time > 90 mg/L
	Day 1	Day 4	Day 1	Day 4
Total patients, n = 60	53 %	52 %	40 %	38 %
With lowest quartile^b of CrCl, n = 11	100 %	86 %	62 %	67 %
With highest quartile^c of CrCl, n = 11	0 %	0 %	9 %	0 %
With RRT, n = 10	80 %	71 %	62 %	57 %
Without RRT, n = 50	48 %	49 %	36 %	33 %
Receiving 2 × 4.5 g PIP/TAZ daily, n = 15^d	100 %	82 %	64 %	50 %
Receiving 3 × 4.5 g PIP/TAZ daily, n = 45^e	38 %	35 %	33 %	32 %

CrCl creatinine clearance, RRT renal replacement therapy, PIP/TAZ piperacillin-tazobactam
^aNumbers as determined on day 1 are presented
^bCreatinine clearance 2–19 mL/min
^cCreatinine clearance 108–233 mL/min
^dComprising on first study day three patients with RRT and 12 patients without RRT. The latter patients presented a median creatinine clearance of 11 mL/min (interquartile range: 6–19 mL/min)
^eComprising on first study day seven patients with RRT and 38 patients without RRT. The latter patients presented a median creatinine clearance of 70 mL/min (interquartile range: 40–130 mL/min)

ISSN: 1364-8535