Skip to main content

Table 2 Distribution of patients in relation to the target ranges of piperacillin

From: Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study

Patient groups, number of patientsa Percentages of patients who attain the targets
trough values ≥ 22.5 mg/L ≥50 % of time > 90 mg/L
Day 1 Day 4 Day 1 Day 4
Total patients, n = 60 53 % 52 % 40 % 38 %
With lowest quartileb of CrCl, n = 11 100 % 86 % 62 % 67 %
With highest quartilec of CrCl, n = 11 0 % 0 % 9 % 0 %
With RRT, n = 10 80 % 71 % 62 % 57 %
Without RRT, n = 50 48 % 49 % 36 % 33 %
Receiving 2 × 4.5 g PIP/TAZ daily, n = 15d 100 % 82 % 64 % 50 %
Receiving 3 × 4.5 g PIP/TAZ daily, n = 45e 38 % 35 % 33 % 32 %
  1. CrCl creatinine clearance, RRT renal replacement therapy, PIP/TAZ piperacillin-tazobactam
  2. aNumbers as determined on day 1 are presented
  3. bCreatinine clearance 2–19 mL/min
  4. cCreatinine clearance 108–233 mL/min
  5. dComprising on first study day three patients with RRT and 12 patients without RRT. The latter patients presented a median creatinine clearance of 11 mL/min (interquartile range: 6–19 mL/min)
  6. eComprising on first study day seven patients with RRT and 38 patients without RRT. The latter patients presented a median creatinine clearance of 70 mL/min (interquartile range: 40–130 mL/min)