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Table 1 Baseline characteristics of patients according to corticosteroid treatment status among critically ill patients with H1N1pdm09

From: The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness

Baseline characteristicsa All patientsb (n = 607) Not treated with corticosteroids (n = 327) Treated with corticosteroids (n = 280) p Valuec
Age, years 47.4 (15.3) 46.2 (15.2) 48.8 (15.3) 0.04
Female sex, n (%) 315 (51.9) 163 (49.9) 152 (54.3) 0.28
BMI, kg/m2 32.0 (10.4) 31.8 (10.7) 32.3 (10.1) 0.62
APACHE II score 20.6 (10.0) 20.1 (9.7) 21.2 (10.3) 0.22
SOFA score, day 1 11.4 (3.7) 11.3 (3.6) 11.4 (3.8) 0.70
SOFA score (cardiovascular), day 1 1.6 (1.5) 1.6 (1.5) 1.6 (1.5) 0.91
PaO2/FiO2 ratio, day 1 155.1 (92.1) 156.3 (91.8) 153.5 (92.4) 0.73
Tidal volume (ml), day 1 514.0 (131.9) 515.8 (119.5) 513.0 (144.2) 0.84
Tidal volume per ideal body weight (ml/kg), day 1 6.2 (2.1) 6.3 (2.1) 6.1 (2.1) 0.56
Positive end-expiratory pressure, (cmH2O), day 1 10.9 (4.6) 10.7 (4.3) 11.1 (4.9) 0.39
Patients with any comorbidities (any) 543 (89.5) 280 (85.6) 263 (93.9) 0.001
Comorbidities per patient, n (%) 3.2 (2.3) 2.8 (2.2) 3.7 (2.4) <0.001
Pulmonary comorbidity, n (%) 195 (32.1) 67 (20.5) 128 (45.7) <0.001
 Asthma, n (%) 124 (20.4) 42 (12.8) 82 (29.3) <0.001
 COPD, n (%) 100 (16.5) 30 (9.2) 70 (25.0) <0.001
Cardiac disease, n (%) 89 (14.7) 40 (12.2) 49 (17.5) 0.07
Hypertension, n (%) 195 (32.1) 102 (31.2) 93 (33.2) 0.60
Obesityd, n (%) 145 (23.9) 74 (22.6) 71 (25.4) 0.43
Diabetes, n (%) 155 (25.7) 80 (24.5) 75 (26.8) 0.51
Immune suppressione, n (%) 35 (5.8) 10 (3.1) 25 (8.9) 0.002
Chronic renal insufficiencyf, n (%) 53 (8.9) 32 (9.8) 21 (7.5) 0.32
Dialysis dependence, n (%) 14 (2.3) 11 (3.4) 3 (1.1) 0.06
Autoimmune disease, n (%) 10 (1.7) 2 (0.6) 8 (2.9) 0.03
Cirrhosis, n (%) 26 (4.3) 14 (4.3) 12 (4.3) 0.99
Bacterial coinfection at admission, n (%) 205 (33.9) 118 (36.1) 87 (31.1) 0.19
Septic shock at admissiong, n (%) 74 (12.3) 33 (10.1) 41 (14.6) 0.09
Pregnant or postpartumh, n (%) 30 (906) 24 (14.7) 6 (4.0) 0.001
  1. APACHE Acute Physiology and Chronic Health Evaluation, BMI body mass index, SOFA Sequential Organ Failure Assessment, COPD chronic obstructive pulmonary disease, day 1 first day in intensive care unit, FiO 2 fraction of inspired oxygen, PaO 2 partial pressure of oxygen in arterial blood;
  2. aMean (standard deviation) unless otherwise specified
  3. bDenominators may vary for each category
  4. c p Value reflects comparison between patients treated and not treated with corticosteroids
  5. dObesity is defined as BMI >30 kg/m2
  6. eImmune suppression; encompasses chemotherapy for malignancy, diagnosis of HIV/AIDS, and other immunosuppression
  7. fChronic renal insufficiency, defined as creatinine >1.5× normal
  8. gSeptic shock at admission as determined by the patient’s physician
  9. hFemale subset