Prevalence and risk factors of hypotension associated with preload-dependence during intermittent hemodialysis in critically ill patients

Table 6 Diagnostic performance of parameters associated with preload dependence-related hypotension in univariate analysis

Parameter	AUC [CI_95%]	Optimal cutoff	Se [CI_95%]	Sp [CI_95%]	FP	FN	PPV	NPV	PLR	NLR	Youden index
PVPI at IHD onset	0.68^† [0.53–0.83]	1.6	0.91 [0.59–1.00]	0.53 [0.42–0.63]	42	1	0.19	0.98	1.93	0.17	0.44
Mechanical ventilation at IHD onset	0.69^† [0.54–0.85]	NA	0.64 [0.32–0.88]	0.75 [0.65–0.83]	24	4	0.23	0.95	2.55	0.15	0.39
HR at IHD onset (min^-1)	0.60 [0.38–0.81]	105	0.36 [0.11–0.69]	0.91 [0.83–0.96]	9	7	0.31	0.93	3.88	0.70	0.27
Dialysate sodium concentration at IHD onset (mmol.L^-1)	0.63 [0.45–0.81]	145	0.82 [0.48–0.98]	0.45 [0.45–0.55]	53	2	0.15	0.96	1.48	0.41	0.27
SAPS II	0.46 [0.30–0.62]	38	0.91 [0.59–1.00]	0.27 [0.19–0.37]	53	2	0.13	0.96	1.24	0.34	0.18

AUC area under the curve, CI _95% 95 % confidence interval, FP false positive, FN false negative, HR heart rate, NA not applicable, NLR negative likelihood ratio, NPV negative predictive value, PLR positive likelihood ratio, PPV positive predictive value, PVPI pulmonary vascular permeability index, SAPS II Simplified Acute Physiology Score II, Se sensitivity, Sp specificity
^†Area under the curve significantly different from 0.5

ISSN: 1364-8535