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Table 1 Contrast echocardiography agents

From: Bedside myocardial perfusion assessment with contrast echocardiography

Classification Gas core Shell Trade name Bubble size (μm) Comments
First generation Air Albumin Albunex 2–8 No longer made
Air Palmitic acid/galactose Levovist (Schering, Kelinworth, NJ) 2–8 Non‐cardiac use mainly
Air D‐galactose Echovist (Berlex, Lachine, Quebec City, Canada) 2–8 First commercially available agent
Second generation Octafluoropropane (C3F8) Albumin Optison (GE healthcare, Chalfont St Giles, UK) 1–10 Available in USA, Europe, South America
Octafluoropropane (C3F8) Lipid Definity (BMS, Billerica, MA) 1–10 Available in USA, Europe, South America, Canada, Australasia
Sulfur hexafluoride (SF6) Lipid Sonovue (Bracca, Milan, Italy) 1–10 Available in Europe and USA (known as Lumason)
  1. NB: The list does not include every available contrast agent worldwide and the accuracy of the ‘comments’ section may change but is up to date at time of writing to the best of the authors’ knowledge