Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis

Zhang, An; Cai, Ying; Wang, Peng-Fei; Qu, Jian-Ning; Luo, Zhen-Chun; Chen, Xiao-Dong; Huang, Bin; Liu, Yi; Huang, Wen-Qi; Wu, Jing; Yin, Yue-Hui

doi:10.1186/s13054-016-1212-x

Critical Care

Table 1 Characteristics of included studies for NGAL to predict AKI in septic patients

From: Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis

Study	Location	Design	Setting	AKI definition	Sepsis definition	Source	AKI/ sepsis (n)	Sampling time (hours)	Storage (°C)	NGAL assay	NGAL test kits
Aydogdu et al. [21]	Turkey	PC	ICU	RIFLE	SCCM/ESICM/ACCP/ATS/SIS	Urine	63/129	NR	−80	ELISA	Biovendor (Brno, Southern Moravia, Czech Republic)
Camou et al. [31] (ClinicalTrials.gov NCT01122225)	France	PC	ICU	RIFLE or AKIN	SCCM/ESICM/ACCP/ATS/SIS	Plasma	43/50	Admission	NR	ELISA	Triage (Biosite Inc., San Diego, CA, USA)
de Geus et al. [34]	Netherlands	PC	ICU	AKIN	ACCP/ SCCM	Plasma	50/75	Admission	−80	ELISA	Triage (Biosite Inc.)
Fan et al. [30]	China	PC	ICU	RIFLE	SCCM/ESICM/ACCP/ATS/SIS	Urine	58/126	Peak	NR	RIA	–
Hjortrup et al. [29] (ClinicalTrials.gov NCT00962156)	Denmark	PC	ICU	KDIGO	ACCP/SCCM	Plasma	31/124	Admission	−80	PETIA	BioProto Diagnostics A/S (Gentofte, Denmark)
Hjortrup et al. [29] (ClinicalTrials.gov NCT00962156)	Denmark	PC	ICU	KDIGO	ACCP/SCCM	Urine	25/100	Admission	−24	PETIA	BioProto Diagnostics A/S (Gentofte, Denmark)
Li and Xu [22]	China	PC	ICU	AKIN	ACCP/SCCM	Urine	17/74	24	−20	ELISA	R&D Systems (Minneapolis, MN, USA)
Martensson et al. [33]	Sweden	NR	ICU	RIFLE or AKIN	ACCP/SCCM	Plasma	18/45	12	NR	RIA	–
Martensson et al. [33]	Sweden	NR	ICU	RIFLE or AKIN	ACCP/SCCM	Urine	18/45	12	NR	RIA	–
Niu et al. [23]	China	PC	ER	AKIN	SCCM/ESICM/ACCP/ATS/SIS	Urine	26/60	12	−80	ELISA	Hycult Biotech (Uden, North Brabant, The Netherlands)
Shapiro et al. [24]	USA	PC	ER	RIFLE	ACCP/SCCM	Plasma	24/66	Admission	−70	ELISA	Triage (Biosite Inc.)
Si et al. [32]	Brazil	PC	ER	AKIN	SSC	Urine	47/168	Admission	−80	ELISA	NR
Wang et al. [25]	China	NR	ICU	KDIGO	ACCP/SCCM	Urine	33/87	48^a	−80	ELISA	R&D Systems
Xing et al. [26]	China	NR	ICU	AKIN	SCCM/ESICM/ACCP/ATS/SIS	Plasma	35/73	NR	−80	ELISA	R&D Systems
Xing et al. [26]	China	NR	ICU	AKIN	SCCM/ESICM/ACCP/ATS/SIS	Urine	35/73	NR	−20	ELISA	R&D Systems
Yan et al. [27]	China	NR	ICU	AKIN	ACCP/SCCM	Urine	57/112	2	−80	ELISA	R&D Systems
Yan and Zang [28]	China	PC	ICU	AKIN	SCCM/ESICM/ACCP/ATS/SIS	Urine	44/141	8	−80	ELISA	R&D Systems
Zhou et al. [35]	China	NR	ICU	AKIN	SCCM/ESICM/ACCP/ATS/SIS	Urine	46/148	8	−80	ELISA	R&D Systems

^aForty-eight hours before AKI
ACCP/SCCM American College of Chest Physicians/Society of Critical Care Medicine, AKI acute kidney injury, AKIN Acute Kidney Injury Network, ELISA enzyme-linked immunosorbent assay, ER emergency room, KDIGO Kidney Disease: Improving Global Outcomes, NGAL neutrophil gelatinase-associated lipocalin, NR not reported, PC prospective cohort, PETIA particle-enhanced turbidimetric immunoassay, RIA radioimmunoassay, RIFLE Risk, Injury, Failure, Loss, End-Stage Kidney Disease, SSC Survival Sepsis Campaign, SCCM/ESICM/ACCP/ATS/SIS Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society

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ISSN: 1364-8535

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