Fig. 3
From: T cells from patients with Candida sepsis display a suppressive immunophenotype
Co-stimulatory molecule expression and markers related to cell activation on CD4 and CD8 T cells. CD28 is a co-stimulatory molecule that is necessary for optimal T cell activation. CD69 is marker of cellular activation. IL-7R activation leads to T cell activation and proliferation. CD28 expression on CD4 T cells was significantly decreased in patients with CBSI, compared to those with CINS. In CD8 T cells, both the percentage and GMFI for CD69 were increased in CBSI compared to CINS. On the other hand, the percentage and GMFI of the IL-7R tended to be lower in CD4 T cells from CBSI versus CINS patients. However, this difference did not reach statistical significance, p = 0.07 and p = 0.08 respectively. Horizontal lines indicate mean or median values. Asterisks indicate significant differences between CINS and CBSI (* p ≤0.05 and ** p ≤0.01). CBSI Candida bloodstream infection, CINS critically ill non-sepsis, GMFI geometric mean fluorescence intensity, IL-7R interleukin-7 receptor