From: Polymicrobial intensive care unit-acquired pneumonia: prevalence, microbiology and outcome
Pathogen, n (%) | Monomicrobial pneumonia n = 215 | Polymicrobial pneumonia n = 41 | P value |
---|---|---|---|
Gram-positive bacteria | |||
Methicillin-sensitive Staphylococcus aureus | 39 (18) | 14 (34) | 0.037 |
Methicillin-resistant Staphylococcus aureus | 18 (8) | 3 (7) | 0.94 |
Streptococcus pneumoniae | 10 (5) | 3 (7) | 0.75 |
Gram-negative bacteria | |||
Enterobacteriaceae | |||
Klebsiella spp. | 14 (7) | 9 (22) | 0.005 |
Escherichia coli | 9 (4) | 10 (24) | <0.001 |
Proteus spp. | 3 (1) | 3 (7) | 0.087 |
Enterobacter spp. | 9 (4) | 6 (15) | 0.025 |
Citrobacter spp. | 2 (1) | 3 (7) | 0.039 |
Serratia spp. | 9 (4) | 6 (15) | 0.025 |
Morganella morganii | 1 (0.5) | 1 (2.4) | 0.73 |
Haemophilus influenza | 6 (3) | 5 (12) | 0.023 |
Non-fermenting Gram-negative bacilli | |||
Stenotrophomonas maltophilia | 12 (6) | 4 (10) | 0.51 |
Pseudomonas aeruginosa | 74 (34) | 12 (29) | 0.65 |
Acinetobacter spp. | 0 | 1 (2.4) | 0.38 |
Moraxella catarrhalis | 2 (0.9) | 1 (2.4) | 0.98 |
Fusobacterium spp. | 0 | 1 (2.4) | 0.38 |
Bacteroides fragilis | 1 (0.5) | 0 | 0.36 |
Fungi | |||
Aspergillus spp. | 6 (3) | 2 (5) | 0.84 |
Bacteremia | 18 (8) | 5 (12) | 0.63 |
Patients with drug-resistant pathogens: | 0.61 | ||
MDR pathogens | 38 (18) | 9 (22) | |
XDR pathogens | 19 (9) | 2 (5) | |
MDR pathogens isolateda: | |||
Methicillin-resistant S. aureus | 18 | 3 | |
Non-fermenting Gram-negative bacilli | 12 | 1 | |
Enterobacteriaceae | 8 | 7 | |
XDR pathogens isolated: | |||
Non-fermenting Gram-negative bacilli | 18 | 2 | |
Enterobacteriaceae | 1 | 0 | |
Microbiologic evolution on day 3: | |||
Persistence of 2 pathogens from day 1 | - | 5 (12) | |
Persistence of 1 pathogen from day 1 | 74 (34) | 13 (32) | |
Persistence + new pathogen isolated | 12 (6) | 0 (0) | |
Eradication but new pathogen isolated | 12 (6) | 1 (2) | |
Eradication of initial pathogen | 71 (33) | 14 (34) | |
Microbiologic evaluation on day 3 not done | 46 (21) | 8 (20) |