Fig. 1
From: Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
Effect of treatment with C5 and CD14 inhibitors on survival in porcine polymicrobial sepsis. Piglets were randomized to receive coversin (C5 inhibitor) and anti-CD14 as treatment (n = 12) or saline (n = 12) in a cecal incision model of sepsis. Sham animals (n = 3) did not undergo cecal incision and were included for reference. Mortality was recorded during the 8-hour period and plotted as a Kaplan-Meier curve. The curves were analyzed using the log-rank (Mantel-Cox) test. C5 complement component 5, CD cluster of differentiation