|
NDI
|
Neocortex
|
CA 1
|
CA 3/4
|
Basal ganglia
|
|---|
|
Control
|
2.25 ± 0.25
|
2.00 ± 0.71
|
2.50 ± 1.10
|
1.00 ± 0.00
|
|
20 pm iNO
|
2.00 ± 0.15
|
2.50 ± 0.50
|
1.60 ± 0.31
|
1.10 ± 0.10
|
|
40 ppm iNO
|
1.60* ± 0.25
|
3.20 ± 1.20
|
1.60 ± 0.40
|
1.00 ± 0.00
|
- Conventional hematoxylin/eosin and NeuN (Mouse anti-Neuronal Nuclei) staining was performed. A neuronal damage index (NDI) was semiquantitatively assessed in neocortex, hippocampal CA1 and CA 3/4 sectors. *P <0.05 for 40 ppm inhaled nitric oxide (iNO) vs. control mean ± standard error of the mean. Data based on cerebral tissue taken from Control animals (n = 4), and animals treated with 20 ppm (n = 10), and 40 ppm (n = 5) iNO
Critical Care