NDI | Neocortex | CA 1 | CA 3/4 | Basal ganglia |
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Control | 2.25 ± 0.25 | 2.00 ± 0.71 | 2.50 ± 1.10 | 1.00 ± 0.00 |
20 pm iNO | 2.00 ± 0.15 | 2.50 ± 0.50 | 1.60 ± 0.31 | 1.10 ± 0.10 |
40 ppm iNO | 1.60* ± 0.25 | 3.20 ± 1.20 | 1.60 ± 0.40 | 1.00 ± 0.00 |
- Conventional hematoxylin/eosin and NeuN (Mouse anti-Neuronal Nuclei) staining was performed. A neuronal damage index (NDI) was semiquantitatively assessed in neocortex, hippocampal CA1 and CA 3/4 sectors. *P <0.05 for 40 ppm inhaled nitric oxide (iNO) vs. control mean ± standard error of the mean. Data based on cerebral tissue taken from Control animals (n = 4), and animals treated with 20 ppm (n = 10), and 40 ppm (n = 5) iNO