| | |
BL
|
PR 30
|
PR 60
|
|---|
|
HR (bpm)
|
Control
|
378 ± 11
|
336 ± 9
|
364 ± 20
|
| |
20 pm iNO
|
360 ± 15
|
344 ± 12
|
372 ± 15
|
| |
40 ppm iNO
|
389 ± 9
|
383 ± 11
|
402 ± 12
|
|
Hgb (g/dL)
|
Control
|
14.5 ± 0.2
|
15.8 ± 0.4
|
16.2 ± 0.5
|
| |
20 pm iNO
|
14.6 ± 0.3
|
15.9 ± 0.2
|
15.5 ± 0.4
|
| |
40 ppm iNO
|
14.2 ± 0.3
|
15.3 ± 0.5
|
15.2 ± 0.4
|
|
CO-Hba (%)
|
Control
|
0.4 ± 0.1
|
0.1 ± 0.1
|
0.4 ± 0.1
|
| |
20 pm iNO
|
0.5 ± 0.1
|
0.8 ± 0.3
|
0.0 ± 1.1
|
| |
40 ppm iNO
|
0.5 ± 0.1
|
0.1 ± 0.5
|
0.4 ± 0.3
|
|
Glucose (mg/dL)
|
Control
|
139 ± 5
|
306 ± 28
|
190 ± 29
|
| |
20 pm iNO
|
129 ± 5
|
240 ± 14
|
179 ± 15
|
| |
40 ppm iNO
|
125 ± 7
|
204 ± 16
|
141 ± 13
|
|
HCO3ˉ
|
Control
|
27.4 ± 0.3
|
14.8 ± 1.7
|
22.2 ± 0.1
|
| |
20 pm iNO
|
27.1 ± 0.4
|
19.2 ± 1.0
|
23.0 ± 0.4
|
| |
40 ppm iNO
|
26.7 ± 0.6
|
18.7 ± 0.6
|
22.7 ± 0.1
|
|
Ph
|
Control
|
7.4 ± 0.0
|
7.2 ± 0.1
|
7.4 ± 0.0
|
| |
20 pm iNO
|
7.4 ± 0.1
|
7.3 ± 0.0
|
7.4 ± 0.0
|
| |
40 ppm iNO
|
7.4 ± 0.1
|
7.3 ± 0.0
|
7.4 ± 0.0
|
|
PaO2 (mmHg)
|
Control
|
131 ± 8
|
301 ± 36
|
121 ± 5
|
| |
20 pm iNO
|
136 ± 9
|
253 ± 38
|
122 ± 11
|
| |
40 ppm iNO
|
124 ± 6
|
271 ± 21
|
132 ± 10
|
|
PaCO2 (mmHg)
|
Control
|
42 ± 2
|
42 ± 3
|
41 ± 3
|
| |
20 pm iNO
|
42 ± 2
|
48 ± 3
|
40 ± 2
|
| |
40 ppm iNO
|
41 ± 1
|
40 ± 2
|
38 ± 1
|
|
Temperature (°C)
|
Control
|
37.4 ± 0.1
|
37.2 ± 0.2
|
37.4 ± 0.1
|
| |
20 pm iNO
|
37.3 ± 0.1
|
37.4 ± 0.1
|
37.4 ± 0.1
|
| |
40 ppm iNO
|
37.4 ± 0.0
|
37.3 ± 0.1
|
37.3 ± 0.1
|
- Physiologic data for control and iNO-treated animals at baseline and after cardiopulmonary resuscitation. Temperature indicates body temperature estimated using a rectal probe. *P <0.05 vs. control; mean ± standard error of the mean. Data based on 10 animals in each group on BL. PR30 and PR60: control, n = 7; 20 ppm, n = 10; 40 ppm, n = 6. BL baseline, PR time post resuscitation in minutes, HR heart rate, Hgb hemoglobin, CO-Hba carboxyhemoglobin in arterial blood, PaO2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension
