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Fig. 7 | Critical Care

Fig. 7

From: Brief inhalation of nitric oxide increases resuscitation success and improves 7-day-survival after cardiac arrest in rats: a randomized controlled animal study

Fig. 7

Successful cardiopulmonary resuscitation resulted in cardiac myofibrillar degeneration detected by luxol fast blue staining (LFB). Cardiac tissue harvested 7 days post cardiac arrest. a Cardiac damage was significantly less pronounced in animals treated with 20 ppm inhaled nitric oxide (iNO) in comparison with untreated controls. Box: bottom and top represent the first and third quartiles, band represents the median, whiskers mark the minimum and maximum of the data. † P <0.05 for 20 ppm iNO vs control. Control, n = 4; 20 ppm, n = 10; 40 ppm, n = 6. b Representative photomicrographs of heart cross-sections with LFB and hematoxylin/eosin (HE) counterstaining of a control, and from a 20-ppm, or 40-ppm iNO-treated animal. The planimetry analysis with imageJ software discriminates between myofibrillar degeneration (LFB blue staining, yellow markers) and undamaged tissue (HE counterstaining, purple)

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Critical Care

ISSN: 1364-8535