Fig. 3
From: Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries
Capillary response time within hypoxic capillary (red blood cell oxygen saturation <20 %). a–e Five 30-second capillary red blood cell (RBC) supply rate (SR, blue circles), RBC hemoglobin O2 saturation (SO2, red squares) and O2 supply rate (qO2, green triangles) (SR–SO2–qO2) profiles. Capillary response time with low RBC saturation (SO2 < 20 %) was assessed as the time required for a capillary to return to a state where RBC SO2 > 20 %. The dashed horizontal red line shown in SR–SO2–qO2 profiles, panels a–e, at SO2 = 20 % is the threshold used to quantify the response. Ovals indicate time intervals in the SR–SO2–qO2 profiles where capillary RBC SO2 had fallen below 20 %. f The capillary response times at both the arteriolar (art-end) and venular (ven-end) ends of capillary networks in sham and cecal ligation and perforation (CLP) animals. Legend with profile statistics (mean (coefficient of variation)), capillary response time is mean (SD). NA not applicable