Long-term mortality and risk factors for development of end-stage renal disease in critically ill patients with and without chronic kidney disease

Table 2 Primary outcome; multivariable Poisson regression analysis of risk of death according to renal function status

Group	n	Deaths	Person years	Mortality rate deaths/person-year (95 % CI)	Crude MRR (95 % CI)	Adjusted MRR^a (95 % CI)	Adjusted MRR^b (95 % CI)
All	103,363	37,836	2.5 × 10⁵	0.151 (0.150–0.153)
No renal disease	92,509	31,530	2.3 × 10⁵	0.135 (0.134–0.137)	1	1	1
AKI	5273	2943	7.6 × 10³	0.387 (0.374–0.402)	2.87 (2.76–2.97)	2.14 (2.06–2.22)	1.15 (1.09–1.21)
Chronic only	3194	2002	4.9 × 10³	0.405 (0.387–0.423)	2.99 (2.86–3.13)	1.75 (1.71–1.86)	1.26 (1.17–1.36)
Acute-on-chronic	998	619	1.3 × 10³	0.478 (0.442–0.518)	3.53 (3.26–3.33)	2.36 (2.18–2.56)	1.38 (1.24–1.54)
ESRD	1389	782	2.8 × 10³	0.281 (0.26–0.30)	2.08 (1.94–2.23)	2.13 (1.98–2.30)	1.46 (1.29–1.67)

MRR are relative to patients in the no renal disease group
^aModel 1: adjusted for age, gender, myocardial infarction and diabetes mellitus with complications.
^bModel 2: fully adjusted model, adjusted for age, gender, SAPS-III score, myocardial infarction, cerebrovascular disease, diabetes mellitus with complications, moderate to severe liver disease, cancer and dementia.
AKI Acute kidney injury, CI Confidence interval, ESRD End-stage renal disease, MRR Mortality rate ratio

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