Table 1 A summary of recent cohort studies into anti-platelet therapy and sepsis/acute respiratory distress syndrome
From: Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome
Reference | Design | Date | Country | Sample size | Investigating | Results |
|---|---|---|---|---|---|---|
[69] | Retrospective observational cohort | 2006 | USA | 161 (68 on ASA 11 other) | Association of pre-hospital APT and risk of ARDS in the critically ill | Decreased incidence of ARDS in APT group but no change in mortality or number of ICU days |
[66] | Three retrospective observational cohorts | 2011 | Germany | 1) 224 | 1) Association of pre-hospital APT and outcome of patients with community-acquired pneumonia | 1) Decreased ICU admission and hospital stay with APT |
2) 615 | 2) Association of pre-hospital APT and outcome of ICU admissions within 24Â hours of hospitalisation | 2) Decreased mortality with APT group | ||||
3) 834 | 3) Association of pre-hospital APT mortality in critically ill patients with sepsis or septic shock | 3) Decreased ICU mortality with the APT group | ||||
[72] | Retrospective cohort study | 2000–2009 | Australia | 5523 | Association of ASA in SIRS or septic shock and mortality | Significant improvement in mortality in ASA group |
[68] | Historical cohort study | 2007–2009 | USA | 651 | Association of pre-hospital ASA and mortality, risk of ARDS, development of septic shock and length of stay in critically ill | No association between pre-hospital ASA use and mortality but reduction in ARDS and decrease in ventilator-free days |
[76] | Secondary analysis of prospective multi-centre international cohort study | 2011 | 20 sites in USA 2 sites in Turkey | 3855 | Association of pre-hospital APT and risk of ARDS | No significant reduction in ARDS in the ASA group |
[75] | Prospective cohort study | 2006–2008 | USA | 575 | Association of pre-hospital APT and risk of ARDS and septic shock in the critically ill | No difference in ARDS or septic shock development with pre-hospital statins or ASA |
[67] | Retrospective cohort | 2010 | Germany | 615 | Association of pre-hospital APT mortality in critically ill | Reduction in mortality in APT group |
[74] | Prospective observational cohort analysis | 2010–2012 | UK | 202 | Association of pre-hospital APT and mortality in ARDS | Reduction in mortality in ASA group |
[83] | Retrospective cohort study | 2013 | Germany | 886 | Association of pre-hospital APT and mortality in critically ill | Significant reduction in mortality with ASA; there was no additional benefit from adding clopidogrel |
[70] | Secondary analysis of prospective study | 2006–2012 | USA | 1149 | Association of pre-hospital APT and risk of ARDS in critically ill | Reduction in mortality with ASA group |
[71] | Secondary analysis of cohort study | 2001–2008 | USA | 839 | Association of pre-hospital APT and risk of MOF, lung dysfunction and mortality in trauma patients | Reduction in risk of lung dysfunction, MOF and possible mortality in trauma patients who received a blood transfusion in APT group |
[65] | Retrospective single-centre study | 2008–2013 | USA | 22 | Association of pre-hospital APT and risk of ARDS in patients with post-aortic valve replacement surgery | No association between ASA and incidence of ARDS in patients with post-aortic valve replacement surgery |
[64] | Observational cohort study | 2000–2010 | Taiwan | 683,421 | Association of pre-hospital APT and mortality in sepsis | Reduction in mortality in APT group |