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Table 3 Multivariate-logistic regression of S1P, SOFA score, PCT, IL-6 CRP, and WBC as predictors of septic shock (dependent variable)

From: Decreased serum concentrations of sphingosine-1-phosphate in sepsis

Variable

Regression coefficient

Odds ratio (95 % CI)

Significance (P value)

S1P, nmol/l

−0.012

0.988 (0.982-0.995)

<0.001

SOFA score, points

+0.481

1.618 (1.146-2.284)

<0.01

a log PCT, μg/l

−0.376

0.686 (0.205-2.299)

n.s.

a log IL-6, ng/l

+0.118

1.126 (0.297-4.262)

n.s.

CRP, mg/l

+0.006

1.006 (0.997-1.016)

n.s.

WBC count, ×109/l

−0.007

0.993 (0.888-1.110)

n.s.

Lactate, nmol/l

+0.511

1.667 (0.900-3.089)

n.s.

  1. S1P sphingosine-1-phosphate, SOFA Sequential Organ Failure Assessment, PCT procalcitonin, IL-6 interleukin-6, CRP C-reactive protein, WBC white blood cell, CI confidence interval, n.s. non-significant
  2. aPCT and IL-6 have been transformed to log10 scale to achieve normal distribution
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Critical Care

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