Fig. 1

Changes in key laboratory parameters from baseline in platelet counts (a), D-dimer levels (b), fibrinogen levels (c), and PT–INR (d). Data are described as group mean ± standard error of the mean. The effect of treatment over time was also statistically significant in all the four parameters: *P <0.05 compared with the control group; †P <0.05 compared with baseline. rhTM recombinant human soluble thrombomodulin, PT–INR prothrombin time–international normalized ratio