Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury

Table 1 Baseline characteristics of Caucasians in FACTT with genotype data (n = 307)

Characteristic	No AKI^a	Stage 1 AKI^a	Stage 2 or 3 AKI^a
	n = 176 (57.3 %)	n = 99 (32.3 %)	n = 32 (10.4 %)
Age, mean years +/− SD	50.4 +/− 14.6	49.9 +/− 16.3	48.8 +/− 16.1
Male gender	48.9 %	52.5 %	62.5 %
Primary ALI risk factor, n (%)
Aspiration	30 (17.1 %)	20 (20.2 %)	2 (6.3 %)
Multiple transfusions	2 (1.1 %)	2 (2.0 %)	0
Pneumonia	81 (46.0 %)	46 (46.5 %)	11 (34.4 %)
Sepsis	30 (17.1 %)	21 (21.2 %)	17 (53.1 %)
Trauma	17 (9.7 %)	6 (6.1 %)	1 (3.1 %)
Other	16 (9.1 %)	4 (4.0 %)	1 (3.1 %)
APACHE III score, mean +/− SD^b	84.4 +/− 25.2	98.8 +/− 30.4	117.4 +/− 26.3
Randomization arm, n (%)
PAC/fluid liberal	47 (26.7 %)	30 (30.3 %)	11 (34.4 %)
PAC/Fluid	43 (24.4 %)	17 (17.2 %)	11 (34.4 %)
Conservative CVC/fluid	39 (22.2 %)	26 (26.3 %)	8 (25.0 %)
Liberal CVC/fluid	47 (26.7 %)	26 (26.3 %)	2 (6.3 %)
Vasopressor use^c	55 (31.3 %)	35 (35.4 %)	19 (59.4 %)
Patient location	86 (48.9 %)	58 (58.6 %)	19 (59.4 %)
MICU SICU	21 (11.9 %)	9 (9.1 %)	0
MICU/SICU	41 (23.3 %)	23 (23.2 %)	4 (12.5 %)
Trauma	16 (9.1 %)	6 (6.1 %)	6 (18.8 %)
Other	12 (6.8 %)	3 (3.0 %)
Baseline creatinine^d, mg/dl (SD)	0.9 (0.4)	1.4 (0.6)	2.1 (1.2)

^aAcute kidney injury (AKI) study definitions: no AKI = <0.3 mg/dl and <50 % increase in serum creatinine (SCr); stage 1 AKI = > =0.3 mg/dl and > = 50 % increase in SCr; stage 2 or 3 AKI = >100 % increase in SCr. ^bMissing acute physiology and chronic health evaluation (APACHE) score for 9 patients, 5 five patients, and patients with no AKI, stage 1 and 2 or 3 AKI, respectively. ^cVasopressor use in the 24 h before Fluid and Catheter Treatment Trial (FACTT) enrollment. ^dBaseline creatinine based on average SCr in the 24 h before enrollment in FACTT. ALI acute lung injury, PAC pulmonary artery catheter, CVC central venous catheter, MICU medical intensive care unit, SICU surgical intensive care unit

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