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Table 1 Clinical and demographic characteristics of the 67 studied patients by outcome category at 6 months post injury

From: Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study

 

Total (n = 67)

Death (GOS = 1)

Unfavorable outcome (GOS = 1–3)

 

Yes (n = 27)

No (n = 40)

P value

Yes (n = 35)

No (n = 32)

P value

Age (yrs, mean ± SD)

37.2 ± 14.3

42.0 ± 16.1

33.9 ± 12.0

0.039

40.0 ± 15.0

34.1 ± 12.9

0.503

Male, n (%)

51 (76.1)

21 (77.8)

30 (75.0)

0.794

28 (80.0)

23 (71.9)

0.436

Cause of injury, n (%)

 Traffic accident

33 (49.3)

13 (48.1)

20 (50.0)

0.968

17 (48.6)

16 (50.0)

0.997

 Fall

26 (38.8)

11 (40.7)

15 (37.5)

14 (40.0)

12 (37.5)

 Violence

6 (8.9)

2 (7.4)

4 (10.0)

3 (8.6)

3 (9.4)

 Other

2 (2.9)

1 (3.7)

1 (2.5)

1 (2.9)

1 (3.1)

Time after injury (hrs, mean ± SD)

2.6 ± 1.1

2.6 ± 1.2

2.6 ± 1.1

0.333

2.4 ± 1.2

2.9 ± 1.1

0.791

GCS, median (range)

6 (3–8)

5 (3–8)

7 (3–8)

0.006

5 (3–8)

7 (3–8)

0.001

 GCS 3–5, n (%)

25

16 (59.3)

9 (22.5)

0.012

19 (54.3)

6 (18.8)

0.006

 GCS 6–8, n (%)

42

11 (40.7)

31 (77.5)

16 (45.7)

26 (81.2)

Pupil reactions, n (%)

 Both present

38

10 (37.0)

28 (41.8)

0.015

13 (37.1)

25 (78.1)

0.032

 At least one unreactive pupil

29

17 (63.0)

12 (58.2)

22 (62.9)

7 (21.9)

Marshall CT classification, n (%)

 Missing

3 (4.5)

1 (3.7)

2 (5)

0.641

1 (2.9)

2 (6.3)

0.406

 Diffuse injury I

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

 Diffuse injury II

7 (10.4)

3 (11.1)

4 (10)

4 (11.4)

3 (9.4)

 Diffuse injury III

11 (16.4)

6 (22.2)

5 (12.5)

6 (17.1)

5 (15.6)

 Diffuse injury IV

13 (19.4)

6 (22.2)

7 (17.5)

10 (28.6)

3 (9.4)

 Evacuated mass lesion

30 (44.8)

11 (40.7)

19 (47.5)

13 (37.1)

17 (53.1)

 Non-evacuated mass lesion

3 (4.5)

0 (0)

3 (7.5)

1 (2.9)

2 (6.3)

Neurosurgery, n (%)

 Yes

59 (88.1)

25 (92.6)

34 (85.0)

0.347

33 (94.3)

26 (81.3)

0.100

 No

8 (11.9)

2 (7.4)

6 (15.0)

2 (5.7)

6 (18.7)

Duration of neurosurgery, (hrs, mean ± SD)a

2.6 ± 1.3

3.1 ± 1.2

2.3 ± 1.3

0.704

3.2 ± 1.2

1.9 ± 1.0

0.216

  1. GOS Glasgow Outcome Scale, yrs years, SD standard deviation, hrs hours, GCS Glasgow Coma Scale, CT computed tomography
  2. aDocumented in 59 of 67 patients