Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to ICU

Table 4 Receiver operating characteristic curve analysis

Scoring tool	AUC	95 % CI	Cut point	Sensitivity	Specificity
Glasgow dataset
RFH	0.84	0.75–0.93	0.41	0.88	0.67
CTP + L	0.83	0.73–0.93	13.5	0.72	0.84
CLIF-SOFA	0.79	0.69–0.89	11.5	0.72	0.78
MELD	0.77	0.66–0.88	16.5	0.88	0.58
SOFA	0.76	0.65–0.87	9.5	0.80	0.61
APACHE II	0.73	0.61–0.85	25.5	0.60	0.76
UKELD	0.72	0.60–0.84	54.5	0.68	0.81
CTP	0.67	0.55–0.80	10.5	0.52	0.74
London dataset
RFH	0.77	0.67–0.86	0.14	0.73	0.75
CTP + L	0.75	0.66–0.84	12.5	0.79	0.63
CLIF-SOFA	0.74	0.65–0.84	10.5	0.76	0.67
SOFA	0.71	0.62–0.81	5.5	0.77	0.61
APACHE II	0.71	0.61–0.80	14.5	0.81	0.50
MELD	0.70	0.60–0.80	20.5	0.63	0.76
UKELD	0.69	0.60–0.79	49.5	0.79	0.58
CTP	0.68	0.59–0.78	8.5	0.88	0.47

Cut points and associated sensitivity and specificity were determined by the Youden’s index obtained from receiver operating characteristic curves. AUC area under the curve, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, MELD model of end-stage liver disease, UKELD United Kingdom model for end-stage liver disease, CTP Child-Turcotte Pugh, CTP + L Child-Turcotte Pugh + lactate, CLIF-SOFA chronic liver failure sequential organ failure assessment, RFH Royal Free Hospital score

ISSN: 1364-8535