|
Group comparison
|
Odds ratio (95 % CI)
|
P value
|
|---|
|
PaCO2 groups
| | |
|
Hypocapnia vs. normocapnia
|
1.39 (1.18–1.63)a
|
<0.001
|
|
Hypercapnia vs. normocapnia
|
1.10 (0.95–1.27)a
|
0.20
|
|
Hypercapnia vs. hypocapnia
|
0.79 (0.67–0.94)a
|
<0.01
|
|
PaO2 groups
| | |
|
Hypoxia vs. normoxia
|
1.34 (1.08–1.66)b
|
<0.01
|
|
Hyperoxia vs. normoxia
|
1.13 (0.81–1.57)b
|
0.46
|
|
Hyperoxia vs. hypoxia
|
0.85 (0.58–1.24)b
|
0.39
|
|
Alternative PaO2 categoriesc
| | |
|
55-80 vs. >300 mmHg
|
1.06 (0.76–1.50)b
|
0.72
|
|
80-102 vs. >300 mmHg
|
0.90 (0.64–1.27)b
|
0.55
|
|
102-300 vs. >300 mmHg
|
0.79 (0.56–1.11)b
|
0.17
|
- Hypocapnia = PaCO2 < 35 mmHg; normocapnia = PaCO2 35–45 mmHg; hypercapnia = PaCO2 > 45 mmHg
- Hypoxia = PaO2 < 60 mmHg; normoxia = PaO2 60–300 mmHg; hyperoxia = PaO2 > 300 mmHg
-
aMultivariable analysis adjusted for age, lowest glucose, AP4-adj and PaO2 (splines)
-
bMultivariable analysis adjusted for age, lowest glucose, AP4-adj and PaCO2 (splines)
-
cStratification based on thresholds from ARDSnet oxygenation target (55–80 mmHg), upper threshold of median cohort quintile (102 mmHg), and threshold from previous studies (300 mmHg)
