Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study

Table 1 Hemodynamics and blood gas data

		BL	PR 10	PR 30	PR 60	PR 360
		iNO n = 10	iNO n = 10	iNO n = 10	iNO n = 10	iNO n = 10
		Control n = 10	Control n = 10	Control n = 10	Control n = 10	Control n = 10
HR (bpm)	iNO	89 ± 16	156 ± 47	130 ± 56	111 ± 22	104 ± 19
	Cont	81 ± 12	192 ± 33	164 ± 33	124 ± 24	102 ± 23
MAP (mmHg)	iNO	91 ± 13	89 ± 8*	72 ± 15	70 ± 14	83 ± 6*
	Cont	94 ± 9	104 ± 14	81 ± 12	78 ± 9	92 ± 10
CO (L/minute)	iNO	5.0 ± 2.1	7.8 ± 2.5	4.3 ± 1.8	3.8 ± 1.5	4.6 ± 0.9
	Cont	5.2 ± 0.9	9.0 ± 1.8	5.4 ± 1.4	3.6 ± 0.7	6.0 ± 2.2
MPAP (mmHg)	iNO	14 ± 44	15 ± 4*	13 ± 3	12 ± 3*	19 ± 5
	Cont	16 ± 4	21 ± 3	16 ± 4	18 ± 4	20 ± 4
P_aO₂ (mmHg)	iNO	139 ± 5	434 ± 92*	329 ± 199	136 ± 6	123 ± 18
	Cont	140 ± 6	504 ± 68	454 ± 174	138 ± 8	135 ± 13
P_aCO₂ (mmHg)	iNO	42 ± 4	40 ± 2	38 ± 3	39 ± 4	43 ± 4
	Cont	41 ± 3	44 ± 5	39 ± 4	38 ± 4	42 ± 5
Lactate (mmol/L)	iNO	1.4 ± 0.7	6.8 ± 1.4	6.9 ± 1.5	5.9 ± 1.9	0.7 ± 0.2
	Cont	1.4 ± 0.2	7.5 ± 1.2	7.3 ± 1.4	5.7 ± 1.1	1.0 ± 0.5
Glucose (mmol/L)	iNO	118 ± 16	277 ± 19	252 ± 25	234 ± 31	117 ± 17*
	Cont	127 ± 13	294 ± 33	274 ± 24	251 ± 29	132 ± 12
pH	iNO	7.47 ± 0.02	7.35 ± 0.03*	7.40 ± 0.06	7.41 ± 0.06	7.46 ± 0.03
	Cont	7.47 ± 0.04	7.30 ± 0.04	7.37 ± 0.04	7.42 ± 0.04	7.47 ± 0.04

Hemodynamic and blood gas data in 20 pigs, treated either with 20 ppm of inhaled nitric oxide (iNO; n = 10) or 0 ppm iNO (Control; n = 10) at baseline (BL) or 10 (PR10), 30 (PR30), 60 (PR60), or 360 (PR360) minutes after return of spontaneous circulation. Results are presented as mean ± SD; *p ≤0.05 for iNO vs Control. HR heart rate, MAP mean arterial pressure, CO cardiac output, MPAP mean pulmonary artery pressure, P_aO₂ arterial oxygen tension, P_aCO₂ arterial carbon dioxide tension

ISSN: 1364-8535