Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome

Table 2 Seventy-two-hour fluid volumes and chloride load by matched cohort

Matched 1:1 Calcium-free balanced: 0.9 % saline cohort fluids
	Calcium-free balanced^a	0.45 % Saline	Lactated Ringer’s	0.9 % Saline	Totals^b
Calcium-free balanced cohort
+ n (%)	1558 (100 %)	73 (4.7 %)	548 (35.2 %)	857 (55.6 %)	1558 (100 %)
Average mmol/L	178.4	88.4	172.8	232.3	112.4
Median mmol/L	98	77 .0	109	154	109.2
Average vol. (median)	1.8 L (1.0 L)	1.1 L (1.0 L)	1.6 L (1.0 L)	1.5 L (1.0 L)	3.3 L (2.0 L)
Vol. range	0.5–10.4 L	0.4–3.0 L	0.5–13.5 L	0.5–16.0 L	0.5–19.8 L
0.9 % Saline cohort
n (%)	Exclusion criteria	54 (3.5 %)	348 (22.3 %)	1558 (100 %)	1558 (100 %)
Average mmol/L		89.3	219	246.5	147.4
Median mmol/L		77	174.4	154	154.0
Average vol. (median)		1.2 L (1.0 L)	2.0 L (1.6 L)	1.6 L (1.0 L)	2.1 L (2 L)
Vol. range		0.5–4.0 L	0.3–10.3 L	0.5–11.6 L	0.5–12.0 L

⁺Note n represents number of patients in the cohort receiving the particular fluid i.e., 73 patients in the calcium-free cohort received 0.45 % saline
^aCalcium-free balanced crystalloid (e.g., Plasma-Lyte or Normosol: Na 140 mmol/L, Cl 98 mmol/L, K 5.0 mmol/L, Mg 1.5 mmol/L, gluconate 23 mmol/L, acetate 27 mmol/L)
^bMonitored fluids (calcium-free balanced, 0.45 % saline, lactated Ringer’s, 0.9 % saline)

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