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Table 3 Comparison of outcomes for patients analysed in the post hoc exploratory analysis with baseline Responsiveness Index (RI) <20

From: A randomized controlled proof-of-concept trial of early sedation management using Responsiveness Index monitoring in mechanically ventilated critically ill patients

Outcome Intervention (n = 19) Control (n = 20) P value
Proportion of hours during the intervention period with RI value <20, median 16 51 0.02
(1st, 3rd quartile; min–max) (11, 45; 2–87) (33, 72; 5–86)
RASS score at baseline, median −4 −4 0.76
(1st, 3rd quartile; min-max) (−4, −3; −5 to −2) (−4, −3; −5 to 0)
Proportion of hours with RASS score −4 or −5 during intervention period, median 47 35 0.63
(1st, 3rd quartile; min-max) (15, 65; 0–94) (10, 72; 0–100)
Total propofol dose (mg) during intervention period, median 1,090 2,380 0.14
(1st, 3rd quartile; min-max) (375, 2,965; 100–7,290) (1,510, 3,730; 60–8,630)
Total alfentanil dose (mg) during intervention period, median 21.2 32.3 0.01
(1st, 3rd quartile; min-max) (8.5, 27.9; 0.0–49.0) (23.3, 49.8; 1.0–87.0)
  1. RASS Richmond agitation-sedation scale