Table 3 Comparison of outcomes for patients analysed in the post hoc exploratory analysis with baseline Responsiveness Index (RI) <20

Proportion of hours during the intervention period with RI value <20, median

16

51

0.02

(1st, 3rd quartile; min–max)

(11, 45; 2–87)

(33, 72; 5–86)

RASS score at baseline, median

−4

−4

0.76

(1st, 3rd quartile; min-max)

(−4, −3; −5 to −2)

(−4, −3; −5 to 0)

Proportion of hours with RASS score −4 or −5 during intervention period, median

47

35

0.63

(1st, 3rd quartile; min-max)

(15, 65; 0–94)

(10, 72; 0–100)

Total propofol dose (mg) during intervention period, median

1,090

2,380

0.14

(1st, 3rd quartile; min-max)

(375, 2,965; 100–7,290)

(1,510, 3,730; 60–8,630)

Total alfentanil dose (mg) during intervention period, median

21.2

32.3

0.01

(1st, 3rd quartile; min-max)

(8.5, 27.9; 0.0–49.0)

(23.3, 49.8; 1.0–87.0)