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Table 1 Characteristics of included studies

From: The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis

Author Year Country Study design Clinical setting Severity of sepsis Control patients Sample size (n) Prevalence (%) Male (%) Mean/medianage (years) Cutoff (pg/ml) TP FP FN TN SEN SPE
Group 1 studies
Kweon [12] 2014 Korea PR ED Sepsis, severe sepsis and septic shock 25 patients without SIRS 118 61.9 50 61.19 (20–91) 430 64 8 9 37 87.7 82.2
Liu [13] 2013 China PR+CR ED Sepsis, severe sepsis and septic shock 100 healthy controls 859 79.2 66.3 79.42 (58–78) 317 481 40 199 239 70.8 85.8
Group 2 studies
Vodnik [14] 2013 Serbia PR ED Sepsis, severe sepsis and septic shock 70 healthy controls 60 50 58.3 54.4 ± 15.5 630 30 2 0 28 100 93
Endo [15] 2012 Japan MPR ED and ICU NA No 185 62.1 59.5 71.8 (17–98) 600 101 13 14 57 87.8 81.4
de Guadiana Romualdo [16] 2014 Spain PR ED NA No 226 16.4 58.4 67 ± 26 729 30 70 7 119 81.1 63
Ishikura [17] 2014 Japan PR ED Sepsis, severe sepsis and septic shock No 82 52.4 53.7 67.2 ± 17.3 647 39 9 4 30 93 76.3
Ulla [18] 2013 Italy MPR ED Sepsis and septic shock No 189 56.1 61.4 64.4 (19–99) 600 84 32 22 51 78.95 61.9
Behnes [11] 2014 Germany PR ICU Severe sepsis and septic shock 60 patients without SIRS 96 84.4 63.1 65.89 (20–88) 530 73 6 8 9 90 60
  1. PR prospective recruitment, MPR multicentre prospective recruitment, CR consecutive recruitment, ED emergency department, NA not available TP true positive, FP false positive, TN true negative, FN false negative, SIRS systemic respiratory response syndrome, SEN sensitivity, SPE specificity