The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis

Table 1 Characteristics of included studies

Author	Year	Country	Study design	Clinical setting	Severity of sepsis	Control patients	Sample size (n)	Prevalence (%)	Male (%)	Mean/medianage (years)	Cutoff (pg/ml)	TP	FP	FN	TN	SEN	SPE
Group 1 studies
Kweon [12]	2014	Korea	PR	ED	Sepsis, severe sepsis and septic shock	25 patients without SIRS	118	61.9	50	61.19 (20–91)	430	64	8	9	37	87.7	82.2
Liu [13]	2013	China	PR+CR	ED	Sepsis, severe sepsis and septic shock	100 healthy controls	859	79.2	66.3	79.42 (58–78)	317	481	40	199	239	70.8	85.8
Group 2 studies
Vodnik [14]	2013	Serbia	PR	ED	Sepsis, severe sepsis and septic shock	70 healthy controls	60	50	58.3	54.4 ± 15.5	630	30	2	0	28	100	93
Endo [15]	2012	Japan	MPR	ED and ICU	NA	No	185	62.1	59.5	71.8 (17–98)	600	101	13	14	57	87.8	81.4
de Guadiana Romualdo [16]	2014	Spain	PR	ED	NA	No	226	16.4	58.4	67 ± 26	729	30	70	7	119	81.1	63
Ishikura [17]	2014	Japan	PR	ED	Sepsis, severe sepsis and septic shock	No	82	52.4	53.7	67.2 ± 17.3	647	39	9	4	30	93	76.3
Ulla [18]	2013	Italy	MPR	ED	Sepsis and septic shock	No	189	56.1	61.4	64.4 (19–99)	600	84	32	22	51	78.95	61.9
Behnes [11]	2014	Germany	PR	ICU	Severe sepsis and septic shock	60 patients without SIRS	96	84.4	63.1	65.89 (20–88)	530	73	6	8	9	90	60

PR prospective recruitment, MPR multicentre prospective recruitment, CR consecutive recruitment, ED emergency department, NA not available TP true positive, FP false positive, TN true negative, FN false negative, SIRS systemic respiratory response syndrome, SEN sensitivity, SPE specificity

ISSN: 1364-8535