Skip to main content

Table 4 Summary of logistic regression models based on plasma acid concentrations (N=138) or urine acid concentrations (N=112) for probability of fatal outcome in participants with severe malaria

From: The role of previously unmeasured organic acids in the pathogenesis of severe malaria

 

Univariate analysis

Multivariate analysis

 

β

(95 % CI)

OR

(95 % CI)

P

β

(95 % CI)

OR

(95 % CI)

P

Regression of plasma acid concentrations

 LA

1.74

(1.00–2.47)

5.67

(2.72–11.86)

<0.001

1.24

(0.43–2.05)

3.45

(1.54–7.76)

0.003

 HPLA

1.76

(1.02–2.51)

5.82

(2.76–12.26)

<0.001

1.25

(0.48–2.02)

3.48

(1.61–7.52)

0.001

 α-HBA

1.22

(0.53–1.91)

3.40

(1.71–6.78)

0.001

–

 

–

  

 β-HBA

1.09

(0.45–1.73)

2.98

(1.57–5.64)

0.001

–

 

–

  

Regression of urine acid concentrations

 LA

0.54

(0.25–0.84)

1.723

(1.28–2.31)

<0.001

0.54

(0.25– 0.84)

1.72

(1.28–2.31)

<0.001

 HPLA

0.58

(0.21–0.96)

1.791

(1.23–2.61)

0.002

–

 

–

  

 α-HBA

0.23

(−0.06 to +0.52)

1.259

(0.94–1.68)

0.118

–

 

–

  

 β-HBA

0.38

(0.02–0.74)

1.459

(1.02–2.09)

0.039

–

 

–

  

 MMA

−0.03

(−0.36 to +0.29)

0.966

(0.70– 1.34)

0.836

–

 

–

  

 EMA

0.12

(−0.22 to +0.46)

1.126

(0.80–1.58)

0.489

–

 

–

  

 α-KGA

−0.13

(−0.43 to +0.16)

0.877

(0.65–1.18)

0.382

–

 

–

  
  1. Abbreviations: OR odds ratio, LA lactic acid, HPLA hydroxyphenyllactic acid, α-HBA α-hydroxybutyric acid, β-HBA β-hydroxybutyric acid, EMA ethylmalonic acid, MMA methylmalonic acid, α-KGA α-ketoglutaric acid, AUROCC area under the receiver operating characteristic curve
  2. Goodness of fit of the plasma acid model: AUROCC=0.81; Hosmer-Lemeshow=0.94; P=0.612, N=138. Goodness of fit of the urine acid model: AUROCC=0.72; Hosmer-Lemeshow=0.72; P=0.459, N=112. Concentrations were log-transformed to normality before analysis. All variables in univariate analysis were initially included in the model, then backward stepwise selection was performed, removing variables on the basis of P≥0.05