From: The role of previously unmeasured organic acids in the pathogenesis of severe malaria
 | Univariate analysis | Multivariate analysis | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
 | β | (95 % CI) | OR | (95 % CI) | P | β | (95 % CI) | OR | (95 % CI) | P |
Regression of plasma acid concentrations | ||||||||||
 LA | 1.74 | (1.00–2.47) | 5.67 | (2.72–11.86) | <0.001 | 1.24 | (0.43–2.05) | 3.45 | (1.54–7.76) | 0.003 |
 HPLA | 1.76 | (1.02–2.51) | 5.82 | (2.76–12.26) | <0.001 | 1.25 | (0.48–2.02) | 3.48 | (1.61–7.52) | 0.001 |
 α-HBA | 1.22 | (0.53–1.91) | 3.40 | (1.71–6.78) | 0.001 | – |  | – |  |  |
 β-HBA | 1.09 | (0.45–1.73) | 2.98 | (1.57–5.64) | 0.001 | – |  | – |  |  |
Regression of urine acid concentrations | ||||||||||
 LA | 0.54 | (0.25–0.84) | 1.723 | (1.28–2.31) | <0.001 | 0.54 | (0.25– 0.84) | 1.72 | (1.28–2.31) | <0.001 |
 HPLA | 0.58 | (0.21–0.96) | 1.791 | (1.23–2.61) | 0.002 | – |  | – |  |  |
 α-HBA | 0.23 | (−0.06 to +0.52) | 1.259 | (0.94–1.68) | 0.118 | – |  | – |  |  |
 β-HBA | 0.38 | (0.02–0.74) | 1.459 | (1.02–2.09) | 0.039 | – |  | – |  |  |
 MMA | −0.03 | (−0.36 to +0.29) | 0.966 | (0.70– 1.34) | 0.836 | – |  | – |  |  |
 EMA | 0.12 | (−0.22 to +0.46) | 1.126 | (0.80–1.58) | 0.489 | – |  | – |  |  |
 α-KGA | −0.13 | (−0.43 to +0.16) | 0.877 | (0.65–1.18) | 0.382 | – |  | – |  |  |