From: The role of previously unmeasured organic acids in the pathogenesis of severe malaria
Characteristics | Uncomplicated malaria N=102 | Severe malaria N=138 | Sepsis N=32 | Encephalopathy N=35 | P value* | ||||
---|---|---|---|---|---|---|---|---|---|
Geo mean | (95 % CI, range) | Geo mean | (95 % CI, range) | Geo mean | (95 % CI, range) | Geo mean | (95 % CI, range) | ||
Plasma concentration (μmol/La) |  |  |  |  |  |  |  |  |  |
 LA | 1680 | (1437–1965, 122–5019) | 4912 | (4389–5497, 835–27,958) | 2615 | (1970–3470, 305–11,002) | 1898 | (1380–2611, 293–17,132) | <0.001 |
 HPLA | 4.3 | (3.7–5.0, UD–13.0) | 10.6 | (9.5–11.8, 4.4–124.7) | 7.0 | (5.4–9.0, UD–30.0) | 4.4 | (3.4–5.6, UD–15.2) | <0.001 |
 α-HBA | 46.0 | (34.6–61.0, UD–270.1) | 117.7 | (106.3–130.4, 30.7–590.1) | 88.4 | (59.4–131.5, UD–411.3) | 86.8 | (63.8–118.1, 6.4–419.7) | <0.001 |
 β-HBA | 102.7 | (91.9–114.8, UD–715.7) | 143.9 | (128.9–160.5, UD–1620.0) | 223.5 | (147.4–338.8, UD–2720.0) | 146.8 | 103.9–207.3, UD–1651.0) | <0.001 |
Corrected urine concentrations (μmol/mmol CrCl)a,b |  | N=78 |  | N=112 |  | N=19 |  | N=26 |  |
 LA | 2.85 | (2.32–3.49, 0.44–41.77) | 12.97 | (9.67–17.40, 0.54–1357.22) | 13.47 | (5.54–32.74, 1.00–555.30) | 10.92 | (6.05–19.72, 1.45–215.30) | <0.001 |
 HPLA | 0.48 | (0.34–0.66, 0.01–7.08) | 1.61 | (1.28–2.04, 0.05–19.61) | 1.15 | (0.46–2.85, 0.03–17.12) | 0.50 | (0.29–0.88, UD–5.82) | <0.001 |
 α-HBA | 0.63 | (0.51–0.78, 0.08–11.86) | 1.26 | (0.98–1.63, UD–79.63) | 1.06 | (0.61–1.84, 0.19–17.37) | 1.16 | (0.91–1.48, 0.36–4.57) | <0.001 |
 β-HBA | 2.11 | (1.75–2.53, UD–11.99) | 3.42 | (2.83–4.12, UD–193.30) | 5.52 | (2.66–11.46, UD–36.28) | 3.40 | (2.27–5.09, UD–17.11) | <0.001 |
 EMA | 0.34 | (0.27–0.43, 0.06–17.46) | 0.26 | (0.21–0.32, UD–9.58) | 0.37 | (0.0.24–0.57, UD–2.33) | 0.36 | (0.26–0.49, UD–2.25) | 0.145 |
 MMA | 0.23 | (0.19–0.28, 0.03–2.85) | 0.20 | (0.16–0.24, UD–2.97) | 0.19 | (0.13–0.27, UD–0.45) | 0.21 | (0.14–0.31, 0.05–4.75) | 0.646 |
 α-KGA | 2.25 | (1.72–2.95, UD–5.44) | 3.18 | (2.53–3.98, UD–27.11) | 3.52 | (1.82–6.82, UD–12.91) | 3.89 | (2.58–5.86, UD–26.41) | 0.128 |