From: The role of previously unmeasured organic acids in the pathogenesis of severe malaria
Characteristics | Uncomplicated malaria N=102 | Severe malaria N=138 | Sepsis N=32 | Encephalopathy N=35 | P value* | ||||
---|---|---|---|---|---|---|---|---|---|
Na+ (mmol/L) | 134 | (4.73, 109–143) | 136 | (6.90, 108–160) | 136 | (11.23, 107–172) | 136 | (9.18, 113–157) | 0.163 |
K+ (mmol/L) | 3.6 | (0.44, 2.4–5.4) | 3.9 | (0.81, 2.1–7.1) | 4.0 | (1.24, 2.0–6.9) | 3.7 | (0.74, 2.0–5.5) | 0.003 |
Mg2+ (mmol/L) | 0.7 | (0.22, 0.1–1.1) | 0.9 | (0.21, 0.5–1.8) | 0.8 | (0.22, 0.3–1.3) | 0.8 | (0.13, 0.4–1.1) | <0.001 |
Ca2+ (mmol/L) | 1.9 | (0.21, 1.4–2.6) | 2.0 | (0.21, 1.4–2.5) | 1.9 | (0.38, 1.1–2.6) | 2.1 | (0.27, 1.3–2.5) | <0.001 |
Cl− (mmol/L) | 102 | (5.16, 87–113) | 105 | (7.87, 72–139) | 106 | (11.50, 78–138) | 100 | (9.73, 75–125) | <0.001 |
l-Lactate (enzymatic assay) (mmol/L), geo mean (95 % CI, range) | 1.7 | (1.6–1.9, 0.8–4.6) | 3.7 | (3.3–4.1, 0.8–14.4) | 2.9 | (2.2–3.8, 0.7–15.8) | 1.9 | (1.4–2.5, 0.3–11.5) | <0.001 |
Albumin (g/L) | 30 | (6.3, 16–46) | 28 | (5.8, 14–49) | 28 | (6.3, 18–41) | 35 | (6.2, 17–47) | <0.001 |
PO43- (mg/dl), geo mean (95 % CI, range) | 0.7 | (0.6–0.8, 0.1–3.0) | 2.1 | (1.8–2.3, 0.5–11.6) | 3.5 | (2.7–4.6, 1.0–12.9) | 2.9 | (2.5–3.3, 1.1–11.7) | <0.001 |
HCO3 − (mmol/L) | 23.6 | (3.4, 15.4–38.9) | 19.0 | (5.4, 3.5–35.8) | 17.0 | (6.1, 4.5–30.8) | 24.2 | (6.5, 3.9–41.3) | <0.001 |
pH | 7.437 | (0.053, 7.308–7.566) | 7.398 | (0.101, 6.931–7.615) | 7.312 | (0.182, 6.623–7.536) | 7.442 | (0.097, 7.054–7.549) | <0.001 |
pCO2 (kPa) | 4.8 | (0.92, 3.1–8.5) | 4.2 | (1.04, 2.2–8.1) | 4.6 | (2.10, 1.8–11.1) | 4.8 | (1.14, 1.9–7.2) | <0.001 |
SBD (mEq/L) | +1 | (+3.6, −15 to +9) | +6 | (+6.6, −11 to +29) | +9 | (+7.6, +3 to +30) | 0 | (+7.6, −19 to +27) | <0.001 |
SIDeff (mEq/L) | 33.5 | (4.3, 22.9–50.8) | 28.1 | (6.1, 10.5–44.4) | 26.8 | (7.5, 11.4–44.2) | 36.4 | (6.9, 18.1–53.8) | <0.001 |
SIDapp (mEq/L) | 39.5 | (4.4, 29.0–52.7) | 36.3 | (6.2, 13.8–52.4) | 35.7 | (7.2, 18.2–49.4) | 43.0 | (4.5, 32.1–53.3) | <0.001 |
SIG (mEq/L) | 6.0 | (3.7, −5.5 to 15.1) | 8.2 | (4.5, −2.4 to 23.4) | 8.6 | (7.7, −4.9 to 30.2) | 6.6 | (5.1, −2.4 to 24.1) | 0.002 |