Rifampin use in acute community-acquired meningitis in intensive care units: the French retrospective cohort ACAM-ICU study

Table 4 Factors associated with ICU mortality in a cohort of 157 patients admitted for bacterial meningitis

Variable	Odds ratio (95 % CI)	p Value
Pulmonary failure	67.7 (3.7–1225.7)	0.004
Renal failure	12.6 (2.2–73.1)	0.005
Cardiovascular failure	9.8 (1.7–57.6)	0.012
Pneumococcal infection	9.0 (1.1–74.8)	0.042
Early antibiotic administration (<2 h)	0.3 (0.0–1.6)	0.155
Hematologic failure	3.6 (0.6–20.6)	0.156
Corticosteroid administration	4.1 (0.5–36.2)	0.200
Age (>75 yr)		NS
Immunosuppression		NS
Female sex		NS
Early treatment with rifampin (<24 h)		NS

Incomplete observations were excluded from the logistic analysis. The presented final model had 134 observations entered and yielded the highest likelihood ratio. Nagelkerke’s R ² was 0.69. The 11 presented variables were those included in the final logistic model
p Values <0.2 are detailed. p Values <0.05 were considered significant (bold)

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