Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

Table 2 Included randomized studies of enteral glutamine supplementation in critically ill patients

Author	Year	ICU population	Setting	All patients	GLN+ patients	GLN− patients	Reference
Houdijk et al.	1998	Critically ill trauma (100 %)	Single center	80	41	39	[24]
Jones et al.	1999	Mixed ICU (6 burns, 6 trauma)	Single center	50	26	24	[25]
Brantley and Pierce	2000	Critically ill trauma (100 %)	Single center	72	31	41	[26]
Hall et al.	2003	Mixed ICU (mostly trauma, 7 burn)	Single center	363	179	184	[27]
Garrel et al.	2003	Burns (TBSA: 20–80 %)	Single center	45	21	24	[28]
Zhou et al.	2003	Severe burns TBSA 50–80 %	Single center	40	20	20	[29]
Peng et al.	2004	Severe burns TBSA >30 %	Single center	48	25	23	[30]
Luo et al.	2008	Mixed ICU Medical-surgical	Single center	30	15	15	[31]
McQuiggan et al.	2008	Shock trauma patients	Single center	20	10	10	[32]
Pattanshetti et al.	2009	Burns (TBSA: 20–60 %)	Single center	30	15	15	[33]
van Zanten et al.	2014	Mixed ICU (109 trauma)	Multicenter	301	152	149	[14]

GLN+ patients treated with glutamine supplemented enteral nutrition, GLN− patients treated with control enteral nutrition, ICU intensive care unit, TBSA total body surface area

ISSN: 1364-8535