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Table 2 Included randomized studies of enteral glutamine supplementation in critically ill patients

From: Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

Author Year ICU population Setting All patients GLN+ patients GLN− patients Reference
Houdijk et al. 1998 Critically ill trauma (100 %) Single center 80 41 39 [24]
Jones et al. 1999 Mixed ICU (6 burns, 6 trauma) Single center 50 26 24 [25]
Brantley and Pierce 2000 Critically ill trauma (100 %) Single center 72 31 41 [26]
Hall et al. 2003 Mixed ICU (mostly trauma, 7 burn) Single center 363 179 184 [27]
Garrel et al. 2003 Burns (TBSA: 20–80 %) Single center 45 21 24 [28]
Zhou et al. 2003 Severe burns TBSA 50–80 % Single center 40 20 20 [29]
Peng et al. 2004 Severe burns TBSA >30 % Single center 48 25 23 [30]
Luo et al. 2008 Mixed ICU Medical-surgical Single center 30 15 15 [31]
McQuiggan et al. 2008 Shock trauma patients Single center 20 10 10 [32]
Pattanshetti et al. 2009 Burns (TBSA: 20–60 %) Single center 30 15 15 [33]
van Zanten et al. 2014 Mixed ICU (109 trauma) Multicenter 301 152 149 [14]
  1. GLN+ patients treated with glutamine supplemented enteral nutrition, GLN− patients treated with control enteral nutrition, ICU intensive care unit, TBSA total body surface area