Table 3 Outcomes of included studies (n = 18)
Outcome studies | Time period | Total donors | Total recipients | Outcomes |
|---|---|---|---|---|
by organ type | n | n | ||
Lung – 3 studies | ||||
• 1 case series [13] | 2002 to 2009 | 66 | 67 | Time to extubation: 21 hours–144 days |
• 1 retrospective cohort [24] | ||||
Hospital stay: 20–59 days | ||||
Primary graft dysfunction: 17–46.9 % | ||||
• 1 prospective cohort [26] | ||||
1-year patient survival: 68 % | ||||
3-year patient survival 57 % | ||||
5-year patient survival 51 % | ||||
No comparisons were made to outcomes using cDCD or DBD donors. | ||||
Kidney – 8 studies | ||||
• 1 database review [14] | 1981 to 2011 | 750 | 629a | Primary graft non-function: 0–22 % |
Delayed graft function: 51–92 % | ||||
1-year graft survival: 87.4–100 % | ||||
3-year graft survival: 100 % | ||||
5-year graft survival: 63–82.1 % | ||||
10-year graft survival: 50 % | ||||
1-year patient survival: 95–100 % | ||||
3-year patient survival: 100 % | ||||
5-year patient survival: 78–90 % | ||||
10-year patient survival: 61 % | ||||
Three studies compared outcomes with DBD donors; two studies reported no significant differences in primary graft non-function, graft survival, and patient survival, but delayed graft function was significantly higher for recipients of uDCD kidneys. | ||||
One study compared outcomes with cDCD donors and reported no difference in any of the outcomes. | ||||
Liver – 5 studies | ||||
• 1 case series [19] | 1994 to 2010 | 122 | 122 | Primary graft non-function: 10–18 % |
1-year graft survival: 50–80 % | ||||
• 1 prospective case–control [20] | 5-year graft survival: 49 % | |||
1-year patient survival: 70–85.5 % | ||||
5-year patient survival: 62 % | ||||
Four studies compared outcomes with DBD donors and reported no significant differences in 1-year graft and patient survival and 5-year patient survival, but primary graft non-function was significantly higher and 5-year graft survival was significantly lower for recipients of uDCD livers | ||||
Kidney and liver – 1 study | ||||
• 1 retrospective cohort [29] | 2008 | 34 K 4 L | NR | No outcomes reported |
Kidney, liver, and lung – 1 study | ||||
• 1 retrospective cohort [21] | 2005 to 2008 | 82 | 158 K 16 L 13 LG | Primary graft non-function of kidneys: 9 % |
Rejection rate of kidneys: 9 % | ||||
Acute rejection rate of liver: 25 % | ||||
No outcomes reported for lungs | ||||