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Table 3 Patient ventilator interaction indices at different levels of PEEPe for PSP and PSN

From: Neural versus pneumatic control of pressure support in patients with chronic obstructive pulmonary diseases at different levels of positive end expiratory pressure: a physiological study

Parameter

Mode

PEEPe0%

PEEPe40%

PEEPe80%

PEEPe120%

P*

TTRIG (ms)

PSP

276 (169, 370)z

198 (156, 357)az

183 (143, 312)abz

154 (33, 236)abcz

<0.001

 

PSN

69 (56, 82)x

54 (32, 70)

59 (17, 82)

76 (54, 90)

 

TCYC-OFF (ms)

PSP

76 (21, 36)z

126 (44, 401)az

130 (47, 432)abz

106 (14, 314)abcz

<0.001

 

PSN

12 (8, 14)x

8 (2, 14)

5 (−2, 12)

2 (−7, 10)

 

NeuroSync index (%)

PSP

29.1 (13.9, 46.8)z

25.3 (15.5, 40.9)az

20.6 (13.5, 37.1)abz

17.7 (10.5, 38.9)abcz

<0.001

 

PSN

5.6 (4.2, 7.8)x

6.0 (4.9, 8.3)

6.2 (5.1, 8.5)

6.7 (3.8, 10.3)

 

EAdi without assist (%)

PSP

0.8 (0, 10.1)

1.1 (0, 18.7)

0 (0, 10.8)

0 (0, 11.4)

<0.001

 

PSN

0 (0, 0)

0 (0, 0)

0 (0, 0)

0 (0, 0)

 

Synchrony (inside box) (%)

PSP

4.7 (0, 16.3)z

7.8 (0, 20)az

11.5 (0, 37.4)abz

7 (0.2, 46.3)abcz

<0.001

 

PSN

89.4 (76.2, 97.9)x

91.3 (76, 95.7)

88 (78, 93)

80 (63.4, 97.4)

 

Dyssynchrony (outside box) (%)

PSP

83.5 (76.3, 92)z

79.3 (63, 86.7)az

76.9 (62, 87.5)abz

70.9 (52.3, 89.3)abcz

<0.001

 

PSN

9 (2.1, 23.1)x

7.3 (1.8, 21.1)

10.8 (6.5, 17.4)

18.6 (2.1, 32.7)

 
  1. Values are presented as median (25–75 % interquartile range). *P values for one-way repeated measures analysis of variance on ranks for the eight conditions: within the same mode: a P <0.05 compared to extrinsic positive end-expiratory pressure (PEEPe)0%; b P <0.05 compared to PEEPe40%; c P <0.05 compared to PEEPe80%. Between modes: z P <0.05 compared to PSN at same PEEPe. Comparison of PSN zero PEEP to PSP optimal PEEP: x P <0.05 PEEPe0% at PSN vs. PEEPe80% at PSP. PSP pneumatically triggered and cycled-off pressure support, PSN neurally triggered and cycled-off pressure support ventilation, PEEPe extrinsic PEEP, TTRIG diaphragm electrical activity (EAdi)-to-trigger time difference, TCYC-OFF cycling-off timing difference