Fig. 3
From: Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model
Evolution of metabolic variables during the experiment. T-60 min is the beginning of stabilization; T 0 min is the time of bacterial injection. Esmolol is started and hemodynamic stabilization occurs between T 120 and T 180 min, and the experiment concluded at T 300 min. ANOVA were performed for each parameter: (a) Lactate, group effect P = 0.486, time effect P = 0.117, time/group effect P = 0.398; (b) O2ERvar, group effect P = 0.026, time effect P = 0.203, time/group effect P = 0.423; (c) VO2var, group effect P = 0.710, time effect P <0.001, time/group effect P = 0.510; (d) DO2var, group effect P = 0.823, time effect P = 0.062, time/group effect P = 0.470. DO2, VO2, O2ER and lactate are expressed as variation (variation are computed as tx divided by tbaseline). Lactate.var, lactate variation, O2ERvar, oxygen extraction ratio computed as the difference between arterial oxygen saturation and central venous oxygen saturation divided by arterial oxygen saturation, VO2var, oxygen consumption, DO2var, oxygen delivery