Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Table 5 Demographic and clinical characteristics of patients with ARDS with DAD versus patients without DAD

Characteristics	DAD (n = 57)	No DAD (n = 44)	p value
Age	56.6 ± 17.5	57.1 ± 16.1	0.876
Gender (male/female)	36/21	29/15	0.775
Immunocompromised (%)	28.1	22.7	0.543
APACHE II score, diagnosis day	22.6 ± 6.1	23.7 ± 5.1	0.506
SOFA score, diagnosis day	6.3 ± 3.7	5.9 ± 2.5	0.492
PaO₂/FiO₂ (mm Hg), diagnosis day	148.6 ± 62.0	134.1 ± 57.3	0.234
SOFA score, biopsy day	7.3 ± 3.9	6.6 ± 2.7	0.326
PaO₂/FiO₂ (mm Hg), biopsy day	158.5 ± 72.5	136.0 ± 59.9	0.099
PEEP (cm H₂O), biopsy day	12.0 ± 3.0	11.5 ± 2.3	0.423
Tidal volume (mL), biopsy day	422.3 ± 95.4	422.4 ± 108.5	0.995
Duration from diagnosis to biopsy (days)	7.6 ± 6.7	7.7 ± 7.1	0.724
Operative complication rate (%)	10.5	15.9	0.423
Treatment changes after biopsy (%)	43.9	54.5	0.287
Hospital mortality (%)	71.9	45.5	0.007*

All values are expressed as number of patients (%) or mean ± SD; *p values <0.05. Abbreviations: DAD Diffuse alveolar damage, ARDS Acute respiratory distress syndrome, APACHE Acute physiology and chronic health evaluation; SOFA Sequential organ failure assessment, PaO₂ Arterial partial pressure of oxygen, FiO₂ Fraction of inspired oxygen, PEEP Positive end-expiratory pressure

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