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Table 5 Demographic and clinical characteristics of patients with ARDS with DAD versus patients without DAD

From: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Characteristics DAD (n = 57) No DAD (n = 44) p value
Age 56.6 ± 17.5 57.1 ± 16.1 0.876
Gender (male/female) 36/21 29/15 0.775
Immunocompromised (%) 28.1 22.7 0.543
APACHE II score, diagnosis day 22.6 ± 6.1 23.7 ± 5.1 0.506
SOFA score, diagnosis day 6.3 ± 3.7 5.9 ± 2.5 0.492
PaO2/FiO2 (mm Hg), diagnosis day 148.6 ± 62.0 134.1 ± 57.3 0.234
SOFA score, biopsy day 7.3 ± 3.9 6.6 ± 2.7 0.326
PaO2/FiO2 (mm Hg), biopsy day 158.5 ± 72.5 136.0 ± 59.9 0.099
PEEP (cm H2O), biopsy day 12.0 ± 3.0 11.5 ± 2.3 0.423
Tidal volume (mL), biopsy day 422.3 ± 95.4 422.4 ± 108.5 0.995
Duration from diagnosis to biopsy (days) 7.6 ± 6.7 7.7 ± 7.1 0.724
Operative complication rate (%) 10.5 15.9 0.423
Treatment changes after biopsy (%) 43.9 54.5 0.287
Hospital mortality (%) 71.9 45.5 0.007*
  1. All values are expressed as number of patients (%) or mean ± SD; *p values <0.05. Abbreviations: DAD Diffuse alveolar damage, ARDS Acute respiratory distress syndrome, APACHE Acute physiology and chronic health evaluation; SOFA Sequential organ failure assessment, PaO2 Arterial partial pressure of oxygen, FiO2 Fraction of inspired oxygen, PEEP Positive end-expiratory pressure