Time course of plasma and urine NGAL, Cys-C, and sTREM-1 levels in non-AKI septic patients (A, C, E) and AKI septic patients (B, D, F). For non-AKI septic patients, the time course of these markers in the plasma and urine was explored since their ICU admission. For the AKI septic patients, the time course was from 72 hours prior to AKI development to 48 hours after the endpoint. Data were presented as mean values and 95% confidence intervals. AKI, acute kidney injury; Cys-C, cystatin C; NGAL, neutrophil gelatinase-associated lipocalin; sTREM-1, soluble triggering receptor expressed on myeloid cells-1.