Table 1 Basic patient characteristics for unmatched (left) and matched (right) patient population
From: Early deep sedation is associated with decreased in-hospital and two-year follow-up survival
Unmatched | Matched (APACHE II and type of admission) | |||||
|---|---|---|---|---|---|---|
Not deeply sedated (n = 1371) | Deeply sedated (n = 513) | P | Not deeply sedated (n = 510) | Deeply sedated (n = 510) | P | |
Age [y] | 68 [59;75] | 64 [50;73] | <0.001 | 68 [58;75] | 64 [50;72] | <0.001 |
Male gender | 881 (64.3%) | 363 (70.8%) | 0.009 | 319 (62.5%) | 361 (70.8%) | 0.006 |
Body mass index | 26.2 [23.6;30.7] | 27.1 [23.5;31.0] | 0.176 | 26.2 [23.8;30.5] | 27.1 [23.5;31.0] | 0.270 |
APACHE II on ICU admission | 20 [16;26] | 25 [18;31] | <0.001 | 25 [18;30] | 25 [18;31] | 0.552 |
Type of admission: | <0.001 | <0.952 | ||||
• Elective surgery | 697 (53.2%) | 136 (27.6%) | 142 (28.5%) | 136 (27.6%) | ||
• Emergency surgery | 348 (26.5%) | 170 (34.5%) | 169 (33.9%) | 170 (34.5%) | ||
• Medical | 266 (20.3%) | 187 (37.9%) | 188 (37.7%) | 187 (37.9%) | ||
Inotropics | <0.001 | <0.001 | ||||
• None | 267 (20.4%) | 29 (5.73%) | 102 (20.7%) | 29 (5.73%) | ||
• Dopamine ≤5 | 176 (13.5%) | 6 (1.19%) | 42 (8.52%) | 6 (1.19%) | ||
• Dopamine >5 or E/NE ≤0.1 | 541 (41.4%) | 115 (22.7%) | 212 (43.0%) | 115 (22.7%) | ||
• Dopamine >15 or E/NE >0.1 | 324 (24.8%) | 356 (70.4%) | 137 (27.8%) | 356 (70.4%) | ||
Sedatives | <0.001 | <0.001 | ||||
• Propofol | 1048 (76.4%) | 191 (37.2%) | 372 (72.9%) | 189 (37.1%) | ||
• Midazolam | 26 (1.9%) | 99 (19.3%) | 15 (2.94%) | 99 (19.4%) | ||
• Both | 129 (9.4%) | 211 (41.1%) | 62 (12.2%) | 210 (41.2%) | ||
• None of above | 168 (12.3%) | 12 (2.34%) | 61 (12.0%) | 12 (2.35%) | ||
First RASS | −4 [−5;-1] | −5 [−5;-4] | <0.001 | −4 [−5;-1] | −5 [−5;-4] | <0.001 |
Time till first RASS [h] | 1 [0;4] | 2 [1;4] | 0.155 | 1 [0;4] | 2 [1;4] | 0.051 |
Time till first RASS >−3 [h] | 11 [5;20] | 78 [52;141] | <0.001 | 11 [4;21] | 79 [52;141] | <0.001 |