Skip to main content

Table 1 Basic patient characteristics for unmatched (left) and matched (right) patient population

From: Early deep sedation is associated with decreased in-hospital and two-year follow-up survival

  Unmatched Matched (APACHE II and type of admission)
  Not deeply sedated (n = 1371) Deeply sedated (n = 513) P Not deeply sedated (n = 510) Deeply sedated (n = 510) P
Age [y] 68 [59;75] 64 [50;73] <0.001 68 [58;75] 64 [50;72] <0.001
Male gender 881 (64.3%) 363 (70.8%) 0.009 319 (62.5%) 361 (70.8%) 0.006
Body mass index 26.2 [23.6;30.7] 27.1 [23.5;31.0] 0.176 26.2 [23.8;30.5] 27.1 [23.5;31.0] 0.270
APACHE II on ICU admission 20 [16;26] 25 [18;31] <0.001 25 [18;30] 25 [18;31] 0.552
Type of admission:    <0.001    <0.952
• Elective surgery 697 (53.2%) 136 (27.6%)   142 (28.5%) 136 (27.6%)  
• Emergency surgery 348 (26.5%) 170 (34.5%)   169 (33.9%) 170 (34.5%)  
• Medical 266 (20.3%) 187 (37.9%)   188 (37.7%) 187 (37.9%)  
Inotropics    <0.001    <0.001
• None 267 (20.4%) 29 (5.73%)   102 (20.7%) 29 (5.73%)  
• Dopamine ≤5 176 (13.5%) 6 (1.19%)   42 (8.52%) 6 (1.19%)  
• Dopamine >5 or E/NE ≤0.1 541 (41.4%) 115 (22.7%)   212 (43.0%) 115 (22.7%)  
• Dopamine >15 or E/NE >0.1 324 (24.8%) 356 (70.4%)   137 (27.8%) 356 (70.4%)  
Sedatives    <0.001    <0.001
• Propofol 1048 (76.4%) 191 (37.2%)   372 (72.9%) 189 (37.1%)  
• Midazolam 26 (1.9%) 99 (19.3%)   15 (2.94%) 99 (19.4%)  
• Both 129 (9.4%) 211 (41.1%)   62 (12.2%) 210 (41.2%)  
• None of above 168 (12.3%) 12 (2.34%)   61 (12.0%) 12 (2.35%)  
First RASS −4 [−5;-1] −5 [−5;-4] <0.001 −4 [−5;-1] −5 [−5;-4] <0.001
Time till first RASS [h] 1 [0;4] 2 [1;4] 0.155 1 [0;4] 2 [1;4] 0.051
Time till first RASS >−3 [h] 11 [5;20] 78 [52;141] <0.001 11 [4;21] 79 [52;141] <0.001
  1. APACHE II, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; E, epinephrine; NE, norepinephrine; RASS, Richmond Agitation-Sedation Score.