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Table 3 Linear regression analyses for tertiles of FGF23 and N-terminal fragment of the prohormone B-type brain natriuretic peptide with different outcome measuresa

From: A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

  

FGF23

NT-proBNP

Dependent variable

Tertile

β (95% CI)

P -value

β (95% CI)

P -value

Duration of surgery

Tertile 1

Reference

 

Tertile 2

12.5 (3.5 to 21.6)

0.007

11.2 (0.6 to 21.7)

0.038

 

Tertile 3

20.7 (10.6 to 30.8)

<0.001

27.9 (16.0 to 39.9)

<0.001

Duration of cardiopulmonary bypass

Tertile 1

Reference

Tertile 2

6.5 (−0.2 to 12.9)

0.057

4.6 (−2.7 to 12.0)

0.215

Tertile 3

16.2 (8.9 to 23.4)

<0.001

22.1 (13.8 to 30.4)

<0.001

Time of hypothermic circulatory arrest

Tertile 1

Reference

Tertile 2

0.4 (−0.5 to 1.2)

0.441

−0.7 (−1.8 to 0.4)

0.241

Tertile 3

2.0 (1.0 to 3.0)

<0.001

0.3 (−0.9 to 1.6)

0.600

Ventilation time

Tertile 1

Reference

 

Tertile 2

2.3 (−12.3 to 16.8)

0.761

−9.6 (−22.7 to 3.5)

0.149

 

Tertile 3

24.8 (8.6 to 40.9)

0.003

6.6 (−8.2-21.3)

0.384

Length of ICU stay

Tertile 1

Reference

 

Tertile 2

0.2 (−0.5 to 0.9)

0.550

−0.5 (−1.2 to 0.2)

0.166

 

Tertile 3

1.3 (0.5 to 2.1)

0.001

0.3 (−0.5 to 1.1)

0.444

Total length of stay

Tertile 1

Reference

 

Tertile 2

0.6 (−0.7 to 1.8)

0.365

0.9 (−0.3 to 2.1)

0.133

 

Tertile 3

1.8 (0.4 to 3.1)

0.009

2.0 (0.6 to 3.3)

0.005

  1. aCI, Confidence interval; FGF23, Fibroblast growth factor 23; ICU, Intensive care unit; NT-proBNP, N-terminal fragment of the prohormone B-type brain natriuretic peptide; RU, Relative units. Data are adjusted for age, sex, mean arterial blood pressure, sinus rhythm, coronary artery disease, chronic heart failure, diabetes, serum creatinine and serum high-sensitivity C-reactive protein. Other models for FGF23 are shown in Additional file 3. For FGF23, tertile 1: ≤50.6 RU/ml, tertile 2: 50.7 to 89.9 RU/ml, tertile 3: ≥90 RU/ml; for NT-proBNP, tertile 1: ≤222 pg/ml, tertile 2: 223 to 1,058 pg/ml, tertile 3: ≥1,059 pg/ml.