| | |
FGF23
|
NT-proBNP
|
|---|
|
Dependent variable
|
Tertile
|
β (95% CI)
|
P
-value
|
β (95% CI)
|
P
-value
|
|---|
|
Duration of surgery
|
Tertile 1
|
Reference
|
| |
Tertile 2
|
12.5 (3.5 to 21.6)
|
0.007
|
11.2 (0.6 to 21.7)
|
0.038
|
| |
Tertile 3
|
20.7 (10.6 to 30.8)
|
<0.001
|
27.9 (16.0 to 39.9)
|
<0.001
|
|
Duration of cardiopulmonary bypass
|
Tertile 1
|
Reference
|
|
Tertile 2
|
6.5 (−0.2 to 12.9)
|
0.057
|
4.6 (−2.7 to 12.0)
|
0.215
|
|
Tertile 3
|
16.2 (8.9 to 23.4)
|
<0.001
|
22.1 (13.8 to 30.4)
|
<0.001
|
|
Time of hypothermic circulatory arrest
|
Tertile 1
|
Reference
|
|
Tertile 2
|
0.4 (−0.5 to 1.2)
|
0.441
|
−0.7 (−1.8 to 0.4)
|
0.241
|
|
Tertile 3
|
2.0 (1.0 to 3.0)
|
<0.001
|
0.3 (−0.9 to 1.6)
|
0.600
|
|
Ventilation time
|
Tertile 1
|
Reference
|
| |
Tertile 2
|
2.3 (−12.3 to 16.8)
|
0.761
|
−9.6 (−22.7 to 3.5)
|
0.149
|
| |
Tertile 3
|
24.8 (8.6 to 40.9)
|
0.003
|
6.6 (−8.2-21.3)
|
0.384
|
|
Length of ICU stay
|
Tertile 1
|
Reference
|
| |
Tertile 2
|
0.2 (−0.5 to 0.9)
|
0.550
|
−0.5 (−1.2 to 0.2)
|
0.166
|
| |
Tertile 3
|
1.3 (0.5 to 2.1)
|
0.001
|
0.3 (−0.5 to 1.1)
|
0.444
|
|
Total length of stay
|
Tertile 1
|
Reference
|
| |
Tertile 2
|
0.6 (−0.7 to 1.8)
|
0.365
|
0.9 (−0.3 to 2.1)
|
0.133
|
| |
Tertile 3
|
1.8 (0.4 to 3.1)
|
0.009
|
2.0 (0.6 to 3.3)
|
0.005
|
-
aCI, Confidence interval; FGF23, Fibroblast growth factor 23; ICU, Intensive care unit; NT-proBNP, N-terminal fragment of the prohormone B-type brain natriuretic peptide; RU, Relative units. Data are adjusted for age, sex, mean arterial blood pressure, sinus rhythm, coronary artery disease, chronic heart failure, diabetes, serum creatinine and serum high-sensitivity C-reactive protein. Other models for FGF23 are shown in Additional file 3. For FGF23, tertile 1: ≤50.6 RU/ml, tertile 2: 50.7 to 89.9 RU/ml, tertile 3: ≥90 RU/ml; for NT-proBNP, tertile 1: ≤222 pg/ml, tertile 2: 223 to 1,058 pg/ml, tertile 3: ≥1,059 pg/ml.
