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Table 3 Linear regression analyses for tertiles of FGF23 and N-terminal fragment of the prohormone B-type brain natriuretic peptide with different outcome measuresa

From: A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

   FGF23 NT-proBNP
Dependent variable Tertile β (95% CI) P -value β (95% CI) P -value
Duration of surgery Tertile 1 Reference
  Tertile 2 12.5 (3.5 to 21.6) 0.007 11.2 (0.6 to 21.7) 0.038
  Tertile 3 20.7 (10.6 to 30.8) <0.001 27.9 (16.0 to 39.9) <0.001
Duration of cardiopulmonary bypass Tertile 1 Reference
Tertile 2 6.5 (−0.2 to 12.9) 0.057 4.6 (−2.7 to 12.0) 0.215
Tertile 3 16.2 (8.9 to 23.4) <0.001 22.1 (13.8 to 30.4) <0.001
Time of hypothermic circulatory arrest Tertile 1 Reference
Tertile 2 0.4 (−0.5 to 1.2) 0.441 −0.7 (−1.8 to 0.4) 0.241
Tertile 3 2.0 (1.0 to 3.0) <0.001 0.3 (−0.9 to 1.6) 0.600
Ventilation time Tertile 1 Reference
  Tertile 2 2.3 (−12.3 to 16.8) 0.761 −9.6 (−22.7 to 3.5) 0.149
  Tertile 3 24.8 (8.6 to 40.9) 0.003 6.6 (−8.2-21.3) 0.384
Length of ICU stay Tertile 1 Reference
  Tertile 2 0.2 (−0.5 to 0.9) 0.550 −0.5 (−1.2 to 0.2) 0.166
  Tertile 3 1.3 (0.5 to 2.1) 0.001 0.3 (−0.5 to 1.1) 0.444
Total length of stay Tertile 1 Reference
  Tertile 2 0.6 (−0.7 to 1.8) 0.365 0.9 (−0.3 to 2.1) 0.133
  Tertile 3 1.8 (0.4 to 3.1) 0.009 2.0 (0.6 to 3.3) 0.005
  1. aCI, Confidence interval; FGF23, Fibroblast growth factor 23; ICU, Intensive care unit; NT-proBNP, N-terminal fragment of the prohormone B-type brain natriuretic peptide; RU, Relative units. Data are adjusted for age, sex, mean arterial blood pressure, sinus rhythm, coronary artery disease, chronic heart failure, diabetes, serum creatinine and serum high-sensitivity C-reactive protein. Other models for FGF23 are shown in Additional file 3. For FGF23, tertile 1: ≤50.6 RU/ml, tertile 2: 50.7 to 89.9 RU/ml, tertile 3: ≥90 RU/ml; for NT-proBNP, tertile 1: ≤222 pg/ml, tertile 2: 223 to 1,058 pg/ml, tertile 3: ≥1,059 pg/ml.