|
Biomarker
|
Number of patients (%)
|
Time frame
|
AUC (95% CI)
|
P
-value
|
Cutoff (ng/ml)
|
Sensitivity (%)
|
Specificity (%)
|
|---|
|
uNGAL
|
59 (59%)
|
T0, 0 to 6 hr
|
0.815 (0.685 to 0.945)
|
<0.001
|
126
|
76
|
84
|
| |
85 (85%)
|
T1, 6 to 12 hr
|
0.780 (0.678 to 0.882)
|
<0.001
|
88
|
70
|
74
|
| |
95 (95%)
|
T2, 12 to 24 hr
|
0.711 (0.599 to 0.824)
|
0.001
|
32
|
72
|
62
|
| |
100 (100%)
|
24-hr peak level
|
0.811 (0.719 to 0.902)
|
<0.001
|
1,338
|
80
|
77
|
|
KIM-1
|
58 (57.4%)
|
T0, 0 to 6 hr
|
0.618 (0.469 to 0.768)
|
0.135
|
0.15
|
52
|
60
|
| |
85 (85%)
|
T1, 6 to 12 hr
|
0.553 (0.469 to 0.729)
|
0.135
|
0.13
|
55
|
60
|
| |
93 (931%)
|
T2, 12 to 24 hr
|
0.737 (0.628 to 0.847)
|
<0.001
|
0.19
|
72
|
67
|
| |
100 (100%)
|
24-hr peak level
|
0.695 (0.584 to 0.807)
|
0.001
|
0.24
|
71
|
62
|
-
aAUC, Area under the receiver operating characteristic curve; CI, Confidence interval; KIM-1, Kidney injury molecule-1; uNGAL, Urinary neutrophil gelatinase-associated lipocalin. The optimal cutoff was based on the Youden index.
