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Table 3 Occurrence of acute kidney injury within 48 hours following intubationa

From: Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study

Biomarker Number of patients (%) Time frame AUC (95% CI) P -value Cutoff (ng/ml) Sensitivity (%) Specificity (%)
uNGAL 59 (59%) T0, 0 to 6 hr 0.815 (0.685 to 0.945) <0.001 126 76 84
  85 (85%) T1, 6 to 12 hr 0.780 (0.678 to 0.882) <0.001 88 70 74
  95 (95%) T2, 12 to 24 hr 0.711 (0.599 to 0.824) 0.001 32 72 62
  100 (100%) 24-hr peak level 0.811 (0.719 to 0.902) <0.001 1,338 80 77
KIM-1 58 (57.4%) T0, 0 to 6 hr 0.618 (0.469 to 0.768) 0.135 0.15 52 60
  85 (85%) T1, 6 to 12 hr 0.553 (0.469 to 0.729) 0.135 0.13 55 60
  93 (931%) T2, 12 to 24 hr 0.737 (0.628 to 0.847) <0.001 0.19 72 67
  100 (100%) 24-hr peak level 0.695 (0.584 to 0.807) 0.001 0.24 71 62
  1. aAUC, Area under the receiver operating characteristic curve; CI, Confidence interval; KIM-1, Kidney injury molecule-1; uNGAL, Urinary neutrophil gelatinase-associated lipocalin. The optimal cutoff was based on the Youden index.