Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study

Table 3 Occurrence of acute kidney injury within 48 hours following intubation^a

Biomarker	Number of patients (%)	Time frame	AUC (95% CI)	P -value	Cutoff (ng/ml)	Sensitivity (%)	Specificity (%)
uNGAL	59 (59%)	T0, 0 to 6 hr	0.815 (0.685 to 0.945)	<0.001	126	76	84
	85 (85%)	T1, 6 to 12 hr	0.780 (0.678 to 0.882)	<0.001	88	70	74
	95 (95%)	T2, 12 to 24 hr	0.711 (0.599 to 0.824)	0.001	32	72	62
	100 (100%)	24-hr peak level	0.811 (0.719 to 0.902)	<0.001	1,338	80	77
KIM-1	58 (57.4%)	T0, 0 to 6 hr	0.618 (0.469 to 0.768)	0.135	0.15	52	60
	85 (85%)	T1, 6 to 12 hr	0.553 (0.469 to 0.729)	0.135	0.13	55	60
	93 (931%)	T2, 12 to 24 hr	0.737 (0.628 to 0.847)	<0.001	0.19	72	67
	100 (100%)	24-hr peak level	0.695 (0.584 to 0.807)	0.001	0.24	71	62

^aAUC, Area under the receiver operating characteristic curve; CI, Confidence interval; KIM-1, Kidney injury molecule-1; uNGAL, Urinary neutrophil gelatinase-associated lipocalin. The optimal cutoff was based on the Youden index.

ISSN: 1364-8535